A global review on short peptides: frontiers and perspectives

V Apostolopoulos, J Bojarska, TT Chai, S Elnagdy… - Molecules, 2021 - mdpi.com
Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

Multiple sclerosis: immunopathology and treatment update

N Dargahi, M Katsara, T Tselios, ME Androutsou… - Brain sciences, 2017 - mdpi.com
The treatment of multiple sclerosis (MS) has changed over the last 20 years. All
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …

Peptide-drug conjugates: a new hope for cancer management

VP Chavda, HK Solanki, M Davidson… - Molecules, 2022 - mdpi.com
Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …

Targeting antigens to dendritic cell receptors for vaccine development

V Apostolopoulos, T Thalhammer… - Journal of drug …, 2013 - Wiley Online Library
Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system
which play a key role in regulating immune responses. Depending on the method of antigen …

Immune gene expression is associated with genomic aberrations in breast cancer

A Safonov, T Jiang, G Bianchini, B Győrffy, T Karn… - Cancer research, 2017 - AACR
The presence of tumor-infiltrating lymphocytes (TIL) is a favorable prognostic factor in breast
cancer, but what drives immune infiltration remains unknown. Here we examine if clonal …

Carbohydrate-based immune adjuvants

N Petrovsky, PD Cooper - Expert review of vaccines, 2011 - Taylor & Francis
The role for adjuvants in human vaccines has been a matter of vigorous scientific debate,
with the field hindered by the fact that for over 80 years, aluminum salts were the only …

Dendritic cell-based vaccine: The state-of-the-art vaccine platform for COVID-19 management

VP Chavda, AB Patel, LK Vora… - Expert review of …, 2022 - Taylor & Francis
Introduction A correlation between new coronaviruses and host immunity, as well as the role
of defective immune function in host response, would be extremely helpful in understanding …

Streptococcusthermophilus ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice

N Dargahi, J Matsoukas, V Apostolopoulos - Brain sciences, 2020 - mdpi.com
Probiotic bacteria have beneficial effects to the development and maintenance of a healthy
microflora that subsequently has health benefits to humans. Some of the health benefits …

Development of PLGA Nanoparticles with a Glycosylated Myelin Oligodendrocyte Glycoprotein Epitope (MOG35–55) against Experimental Autoimmune …

I Triantafyllakou, N Clemente, RK Khetavat… - Molecular …, 2022 - ACS Publications
Multiple sclerosis (MS) is one of the most common neurodegenerative diseases in young
adults, with early clinical symptoms seen in the central nervous system (CNS) myelin …

Small Extracellular Vesicles Derived from Altered Peptide Ligand‐Loaded Dendritic Cell Act as A Therapeutic Vaccine for Spinal Cord Injury Through Eliciting CD4+ …

S Wang, G Li, X Liang, Z Wu, C Chen… - Advanced …, 2024 - Wiley Online Library
The balance among different CD4+ T cell subsets is crucial for repairing the injured spinal
cord. Dendritic cell (DC)‐derived small extracellular vesicles (DsEVs) effectively activate T …