Oral cancer is the sixth most common cancer type in the world, and 90% of it is represented
by oral squamous cell carcinoma (OSCC). Despite progress in preventive and therapeutic …

Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating
and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of …

Cancers are caused by mutations that may be inherited, induced by environmental factors,
or result from DNA replication errors (R). We studied the relationship between the number of …

Background & Aims Multigene panels are commercially available tools for hereditary cancer
risk assessment that allow for next-generation sequencing of numerous genes in parallel …

Recently, many new approaches, study designs, and statistical and analytical methods have
emerged for studying gene-environment interactions (G× Es) in large-scale studies of …

Scientific and technologic advances are revolutionizing our approach to genetic cancer risk
assessment, cancer screening and prevention, and targeted therapy, fulfilling the promise of …

Prediction of phenotypic consequences of mutations constitutes an important aspect of
precision medicine. Current computational tools mostly rely on evolutionary conservation …

Next-generation sequencing (NGS) has enabled whole-exome and whole-genome
sequencing of tumors for causative mutations, allowing for more accurate targeting of …

Genome-wide association studies (GWAS) detect common genetic variants associated with
complex disorders. With their comprehensive coverage of common single nucleotide …

A number of case-control studies regarding the association of the polymorphisms in the
programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) genes with …