[HTML][HTML] Mechanisms and disease consequences of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
Immunotherapies for hepatocellular carcinoma
JM Llovet, F Castet, M Heikenwalder… - Nature reviews Clinical …, 2022 - nature.com
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma
AX Zhu, AR Abbas, MR de Galarreta, Y Guan, S Lu… - Nature medicine, 2022 - nature.com
Atezolizumab (anti-programmed death-ligand 1 (PD-L1)) and bevacizumab (anti-vascular
endothelial growth factor (VEGF)) combination therapy has become the new standard of …
endothelial growth factor (VEGF)) combination therapy has become the new standard of …
The immunological and metabolic landscape in primary and metastatic liver cancer
X Li, P Ramadori, D Pfister, M Seehawer… - Nature Reviews …, 2021 - nature.com
The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …
[HTML][HTML] Immune cell-mediated features of non-alcoholic steatohepatitis
T Huby, EL Gautier - Nature Reviews Immunology, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations,
starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis …
starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis …
[HTML][HTML] Cabozantinib plus atezolizumab versus sorafenib for advanced hepatocellular carcinoma (COSMIC-312): a multicentre, open-label, randomised, phase 3 trial
RK Kelley, L Rimassa, AL Cheng, A Kaseb, S Qin… - The Lancet …, 2022 - Elsevier
Background Cabozantinib has shown clinical activity in combination with checkpoint
inhibitors in solid tumours. The COSMIC-312 trial assessed cabozantinib plus atezolizumab …
inhibitors in solid tumours. The COSMIC-312 trial assessed cabozantinib plus atezolizumab …
XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis
A Deczkowska, E David, P Ramadori, D Pfister… - Nature medicine, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are
prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver …
prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver …
PD-L1, TMB, and other potential predictors of response to immunotherapy for hepatocellular carcinoma: how can they assist drug clinical trials?
A Rizzo, AD Ricci - Expert opinion on investigational drugs, 2022 - Taylor & Francis
Introduction Hepatocellular carcinoma (HCC) represents the sixth most commonly
diagnosed malignancy worldwide, accounting for millions of deaths annually. Despite …
diagnosed malignancy worldwide, accounting for millions of deaths annually. Despite …
Molecular pathogenesis and systemic therapies for hepatocellular carcinoma
JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature Cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …
The poor outcome associated with HCC is dramatically changing due to the advent of …
[HTML][HTML] Prognosis of patients with hepatocellular carcinoma treated with immunotherapy–development and validation of the CRAFITY score
B Scheiner, K Pomej, MM Kirstein, F Hucke… - Journal of …, 2022 - Elsevier
Background & Aims Immunotherapy with atezolizumab plus bevacizumab represents the
new standard of care in systemic front-line treatment of hepatocellular carcinoma (HCC) …
new standard of care in systemic front-line treatment of hepatocellular carcinoma (HCC) …