[HTML][HTML] Circular RNAs: Characterization, cellular roles, and applications

CX Liu, LL Chen - Cell, 2022 - cell.com
Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs.
Recent technological advances have in part overcome problems with their circular …

Biogenesis and regulatory roles of circular RNAs

L Yang, JE Wilusz, LL Chen - Annual review of cell and …, 2022 - annualreviews.org
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …

The expanding regulatory mechanisms and cellular functions of circular RNAs

LL Chen - Nature reviews Molecular cell biology, 2020 - nature.com
Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …

Best practice standards for circular RNA research

AF Nielsen, A Bindereif, I Bozzoni, M Hanan… - Nature …, 2022 - nature.com
Circular RNAs (circRNAs) are formed in all domains of life and via different mechanisms.
There has been an explosion in the number of circRNA papers in recent years; however, as …

The functional roles of the circRNA/Wnt axis in cancer

C Xue, G Li, Q Zheng, X Gu, Z Bao, J Lu, L Li - Molecular Cancer, 2022 - Springer
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

Biogenesis and functions of circular RNAs come into focus

MS Xiao, Y Ai, JE Wilusz - Trends in cell biology, 2020 - cell.com
Many eukaryotic protein-coding genes are able to generate exonic circular RNAs. Most of
these covalently linked transcripts are expressed at low levels, but some accumulate to …

Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long

J Zhang, L Hou, Z Zuo, P Ji, X Zhang, Y Xue… - Nature …, 2021 - nature.com
Reconstructing the sequence of circular RNAs (circRNAs) from short RNA sequencing reads
has proved challenging given the similarity of circRNAs and their corresponding linear …

Nanomedicine-based approaches for mRNA delivery

S Uchida, F Perche, C Pichon… - Molecular …, 2020 - ACS Publications
Messenger RNA (mRNA) has immense potential for developing a wide range of therapies,
including immunotherapy and protein replacement. As mRNA presents no risk of integration …

Structured elements drive extensive circular RNA translation

CK Chen, R Cheng, J Demeter, J Chen… - Molecular cell, 2021 - cell.com
The human genome encodes tens of thousands circular RNAs (circRNAs) with mostly
unknown functions. Circular RNAs require internal ribosome entry sites (IRES) if they are to …

Dynamic imaging of nascent RNA reveals general principles of transcription dynamics and stochastic splice site selection

Y Wan, DG Anastasakis, J Rodriguez, M Palangat… - Cell, 2021 - cell.com
The activities of RNA polymerase and the spliceosome are responsible for the heterogeneity
in the abundance and isoform composition of mRNA in human cells. However, the dynamics …