[HTML][HTML] Circular RNAs: Characterization, cellular roles, and applications
CX Liu, LL Chen - Cell, 2022 - cell.com
Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs.
Recent technological advances have in part overcome problems with their circular …
Recent technological advances have in part overcome problems with their circular …
Biogenesis and regulatory roles of circular RNAs
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …
The expanding regulatory mechanisms and cellular functions of circular RNAs
LL Chen - Nature reviews Molecular cell biology, 2020 - nature.com
Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …
Best practice standards for circular RNA research
AF Nielsen, A Bindereif, I Bozzoni, M Hanan… - Nature …, 2022 - nature.com
Circular RNAs (circRNAs) are formed in all domains of life and via different mechanisms.
There has been an explosion in the number of circRNA papers in recent years; however, as …
There has been an explosion in the number of circRNA papers in recent years; however, as …
The functional roles of the circRNA/Wnt axis in cancer
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …
Biogenesis and functions of circular RNAs come into focus
Many eukaryotic protein-coding genes are able to generate exonic circular RNAs. Most of
these covalently linked transcripts are expressed at low levels, but some accumulate to …
these covalently linked transcripts are expressed at low levels, but some accumulate to …
Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long
Reconstructing the sequence of circular RNAs (circRNAs) from short RNA sequencing reads
has proved challenging given the similarity of circRNAs and their corresponding linear …
has proved challenging given the similarity of circRNAs and their corresponding linear …
Nanomedicine-based approaches for mRNA delivery
Messenger RNA (mRNA) has immense potential for developing a wide range of therapies,
including immunotherapy and protein replacement. As mRNA presents no risk of integration …
including immunotherapy and protein replacement. As mRNA presents no risk of integration …
Structured elements drive extensive circular RNA translation
The human genome encodes tens of thousands circular RNAs (circRNAs) with mostly
unknown functions. Circular RNAs require internal ribosome entry sites (IRES) if they are to …
unknown functions. Circular RNAs require internal ribosome entry sites (IRES) if they are to …
Dynamic imaging of nascent RNA reveals general principles of transcription dynamics and stochastic splice site selection
The activities of RNA polymerase and the spliceosome are responsible for the heterogeneity
in the abundance and isoform composition of mRNA in human cells. However, the dynamics …
in the abundance and isoform composition of mRNA in human cells. However, the dynamics …