Revolution of Alzheimer precision neurology. Passageway of systems biology and neurophysiology

H Hampel, N Toschi, C Babiloni… - Journal of …, 2018 - content.iospress.com
The Precision Neurology development process implements systems theory with system
biology and neurophysiology in a parallel, bidirectional research path: a combined …

Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease

SJ Teipel, M Grothe, S Lista, N Toschi… - Medical …, 2013 - medical.theclinics.com
Alzheimer disease (AD) is the most common cause of dementia in the elderly. Autopsy case
series on the sequential accumulation of neurofibrillary bundles and amyloid plaques, as …

Plasma phospholipids identify antecedent memory impairment in older adults

M Mapstone, AK Cheema, MS Fiandaca, X Zhong… - Nature medicine, 2014 - nature.com
Alzheimer's disease causes a progressive dementia that currently affects over 35 million
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …

Characterization of anomalous diffusion in porous biological tissues using fractional order derivatives and entropy

RL Magin, C Ingo, L Colon-Perez, W Triplett… - Microporous and …, 2013 - Elsevier
In this high-resolution magnetic resonance imaging (MRI) study at 17.6 Tesla of a fixed rat
brain, we used the continuous time random walk theory (CTRW) for Brownian motion to …

The critical need for defining preclinical biomarkers in Alzheimer's disease

MS Fiandaca, ME Mapstone, AK Cheema… - Alzheimer's & …, 2014 - Wiley Online Library
The increasing number of afflicted individuals with late‐onset Alzheimer's disease (AD)
poses significant emotional and financial burden on the world's population. Therapeutics …

Diffusion-weighted intravoxel incoherent motion imaging of renal tumors with histopathologic correlation

H Chandarana, SK Kang, S Wong… - Investigative …, 2012 - journals.lww.com
Purpose The aim of this study was to use intravoxel incoherent motion diffusion-weighted
imaging to discriminate subtypes of renal neoplasms and to assess agreement between …

On random walks and entropy in diffusion‐weighted magnetic resonance imaging studies of neural tissue

C Ingo, RL Magin, L Colon‐Perez… - Magnetic resonance …, 2014 - Wiley Online Library
Purpose In diffusion‐weighted MRI studies of neural tissue, the classical model assumes the
statistical mechanics of Brownian motion and predicts a monoexponential signal decay …

Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: a long-range point of view beyond 2020

H Hampel, S Lista, SJ Teipel, F Garaci, R Nisticò… - Biochemical …, 2014 - Elsevier
Recent advances in understanding the molecular mechanisms underlying various paths
toward the pathogenesis of Alzheimer's disease (AD) has begun to provide new insight for …

Non-Gaussian diffusion imaging: a brief practical review

S De Santis, A Gabrielli, M Palombo… - Magnetic resonance …, 2011 - Elsevier
The departure from purely mono-exponential decay of the signal, as observed from brain
tissue following a diffusion-sensitized sequence, has prompted the search for alternative …

CSF Aβ1-42 combined with neuroimaging biomarkers in the early detection, diagnosis and prediction of Alzheimer's disease

S Lista, FG Garaci, M Ewers, S Teipel, H Zetterberg… - Alzheimer's & …, 2014 - Elsevier
The development of validated, qualified, and standardized biomarkers for Alzheimer's
disease (AD) that allow for an early presymptomatic diagnosis and discrimination …