Systemic sclerosis (SSc) is a complex disease characterized by early microvascular
abnormalities, immune dysregulation and chronic inflammation, and subsequent fibrosis of …

Vitamin D, referring to the two forms, D2 from the diet and D3 primarily derived from
phototransformation in the skin, is a prohormone important in human health. The most …

Systemic sclerosis (scleroderma, SSc) is an incurable autoimmune disease with high
morbidity and mortality rates. Here, we conducted a population-scale single-cell genomic …

Systemic sclerosis is a complex autoimmune disease characterized by a chronic and
frequently progressive course and by extensive patient-to-patient variability. Like other …

Interstitial lung disease (ILD) encompasses a large and diverse group of pathological
conditions that share similar clinical, radiological and pathological manifestations, despite …

Fibrosis is a pathological process characterized by excessive accumulation of connective
tissue components in an organ or tissue. Fibrosis is produced by deregulated wound …

Objectives Rituximab (RTX) may favorably affect lung function and skin fibrosis in patients
with systemic sclerosis (SSc). We aimed to assess long-term efficacy and safety of RTX in …

The past 10 years have seen the publication of results from several multicentre clinical trials
in primary and systemic sclerosis (SSc)-related Raynaud phenomenon. The publication of …

Endothelial cell damage and platelet activation contribute to sustained vasculopathy, which
is a key clinical characteristic of systemic sclerosis (SSc), also known as scleroderma …

Fibrosis is a major cause of mortality worldwide, characterized by myofibroblast activation
and excessive extracellular matrix deposition. Systemic sclerosis is a prototypic fibrotic …