Capillary leak and edema after resuscitation: The potential contribution of reduced endothelial shear stress caused by hemodilution

D Walsh, C Cunning, G Lee, J Boylan, P McLoughlin - Shock, 2023 - journals.lww.com
Normal shear stress is essential for the normal structure and functions of the
microcirculation. Hemorrhagic shock leads to reduced shear stress due to reduced tissue …

Post-reconstitution hemostatic stability profiles of canadian and german freeze-dried plasma

HT Peng, K Moes, K Singh, SG Rhind, C Pambrun… - Life, 2024 - mdpi.com
Despite the importance of the hemostatic properties of reconstituted freeze-dried plasma
(FDP) for trauma resuscitation, few studies have been conducted to determine its post …

Evaluating the effects of hypoxic storage on platelet function and health using a novel storage system

AJ Weaver Jr, CS McIntosh, SG Kelly, GD Barrera… - …, 2024 - Wiley Online Library
Background Thousands of units of whole blood (WB) and blood components are transfused
daily to treat trauma patients. Improved methods for blood storage are critical to support …

[HTML][HTML] Design of the randomized controlled trial comparing dimethyl sulfoxide cryopreserved platelets to liquid stored platelets in patients undergoing …

G Whitman, R Kramer, K Tanaka, J Holcomb… - JTCVS open, 2023 - Elsevier
Objective Dimethylsulfoxide-cryopreserved platelets are being evaluated for treatment of
acute hemorrhage in patients with thrombocytopenia or platelet dysfunction when liquid …

Forecasting demands of blood components based on prediction models

Y Wang, W Zhang, Q Rao, Y Ma, X Ding… - Transfusion Clinique et …, 2024 - Elsevier
Background An adequate blood supply is an important guarantee for saving lives and
protecting health. In order to manage the blood supply more effectively when the condition of …

Facing futility in hemorrhagic shock: when to say 'when'in children and adults

BA Cotton - Trauma Surgery & Acute Care Open, 2024 - tsaco.bmj.com
The last two decades have seen increased efforts at early identification of those likely to
require life-saving interventions such as rapid response teams, massive transfusion delivery …

Platelet function in trauma: is current technology in function testing missing the mark in injured patients?

JB Schriner, MJ George, JC Cardenas, SD Olson… - Shock, 2022 - journals.lww.com
Platelets are subcellular anucleate components of blood primarily responsible for initiating
and maintaining hemostasis. After injury to a blood vessel, platelets can be activated via …

Optimizing Mass Casualty Triage: Using Discrete Event Simulation to Minimize Time to Resuscitation

NM Igra, D Schmulevich, Z Geng… - Journal of the …, 2023 - journals.lww.com
Background: Urban areas in the US are increasingly focused on mass casualty incident
(MCI) response. We simulated pre-hospital triage scenarios and hypothesized that using …

Addressing platelet insecurity–A national call to action

EA Gehrie, PP Young, SV Basavaraju, AW Bracey… - Transfusion - Wiley Online Library
Over the past several years, blood centers, hospitals, and military services have been
subject to an unpredictable supply of platelets for transfusion. While the platelet supply has …

Transfusion Requirement During Mass Casualty Events: Improving Preparedness Through Simulation and Real-Life Experience

N Py, T Martinez, P Pasquier - Shock, 2022 - journals.lww.com
The opinions or assertions expressed herein are the private views of the authors and are not
to be considered as official or as reflecting the views of the French Military Medical Service …