Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Acute ischaemic stroke accounts for 6.5 million deaths per year, and by 2030 will result in
the annual loss of over 200 million disability-adjusted life years globally. There have been …

Stroke occurs when a cerebral blood vessel is blocked or ruptured, and it is the major cause
of death and adult disability worldwide. Various pharmacological agents have been …

Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of
stroke severities, from mild to substantial, can be achieved. This review describes …

Mitochondria lie at the crossroads of neuronal survival and cell death. They play important
roles in cellular bioenergetics, control intracellular Ca2+ homeostasis, and participate in key …

Stroke is the result of blockage or rupture of blood vessels in the brain and is the leading
cause of death and disability in the world. Currently only a very limited number of therapeutic …

The clinical relevance of the transient intraluminal filament model of middle cerebral artery
occlusion (tMCAO) has been questioned due to distinct cerebral blood flow profiles upon …

Background Obesity increases the risk for ischaemic stroke and is associated with worse
outcome clinically and experimentally. Most experimental studies have used genetic models …

Wnt signaling is a conserved pathway involved in expansion of neural progenitors and
lineage specification during development. However, the role of Wnt signaling in the post …

Ischemic stroke, the second leading cause of death worldwide, leads to excessive glutamate
release, over-activation of N-methyl-D-aspartate receptor (NMDAR), and massive influx of …