Role of the inflammasome in insulin resistance and type 2 diabetes mellitus
S Lu, Y Li, Z Qian, T Zhao, Z Feng, X Weng… - Frontiers in …, 2023 - frontiersin.org
The inflammasome is a protein complex composed of a variety of proteins in cells and which
participates in the innate immune response of the body. It can be activated by upstream …
participates in the innate immune response of the body. It can be activated by upstream …
Research progress of targeting NLRP3 inflammasome in peripheral nerve injury and pain
W Li, J Liang, S Li, L Wang, S Xu, S Jiang… - International …, 2022 - Elsevier
Nerve injury and nerve pain are common diseases caused by neuroinflammation.
Numerous studies have shown that the activation of NLRP3 (nod-like receptor family, pyrin …
Numerous studies have shown that the activation of NLRP3 (nod-like receptor family, pyrin …
Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway
H Chen, J Zhu, Y Le, J Pan, Y Liu, Z Liu, C Wang… - Phytomedicine, 2022 - Elsevier
Background Doxorubicin-induced cardiotoxicity (DIC) limits the clinical application of the
drug in treatment of cancers and imposes a severe health burden on the patients. Therefore …
drug in treatment of cancers and imposes a severe health burden on the patients. Therefore …
The upregulation of NLRP3 inflammasome in dorsal root ganglion by ten-eleven translocation methylcytosine dioxygenase 2 (TET2) contributed to diabetic …
W Chen, X Wang, Q Sun, Y Zhang, J Liu, T Hu… - Journal of …, 2022 - Springer
Background The nucleotide oligomerization domain (NOD)-like receptor family pyrin domain
containing 3 (NLRP3) in dorsal root ganglion (DRG) contributes to pain hypersensitivity in …
containing 3 (NLRP3) in dorsal root ganglion (DRG) contributes to pain hypersensitivity in …
Anti-neuropathic pain activity of Ajugarin-I via activation of Nrf2 signaling and inhibition of TRPV1/TRPM8 nociceptors in STZ-induced diabetic neuropathy
This study aimed to investigate the anti-neuropathic pain activity and its underlying
molecular mechanism of Ajugarin-I (Aju-I) in a rat model of diabetic neuropathic pain. The …
molecular mechanism of Ajugarin-I (Aju-I) in a rat model of diabetic neuropathic pain. The …
Salidroside attenuates high altitude hypobaric hypoxia-induced brain injury in mice via inhibiting NF-κB/NLRP3 pathway
S Jiang, F Fan, L Yang, K Chen, Z Sun, Y Zhang… - European Journal of …, 2022 - Elsevier
Salidroside (Sal), an active ingredient from Rhodiola crenulate, has been reported to exert
neuroprotection in cerebral injury from hypobaric hypoxia (HH) at high altitude. However, it …
neuroprotection in cerebral injury from hypobaric hypoxia (HH) at high altitude. However, it …
[HTML][HTML] Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB …
J Liu, W Ma, CH Zang, GD Wang… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background The NOD-like receptor family pyrin domain-containing 3 (NLRP3)
inflammasome is an important mediator of neuroinflammatory responses that regulates …
inflammasome is an important mediator of neuroinflammatory responses that regulates …
Ferroptosis-regulated cell death as a therapeutic strategy for neurodegenerative diseases: current status and future prospects
JB Zhang, X Jia, Q Cao, YT Chen, J Tong… - ACS chemical …, 2023 - ACS Publications
Ferroptosis is increasingly being recognized as a key element in the pathogenesis of
diverse diseases. Recent studies have highlighted the intricate links between iron …
diverse diseases. Recent studies have highlighted the intricate links between iron …
Probucol attenuates NF-κB/NLRP3 signalling and augments Nrf-2 mediated antioxidant defence in nerve injury induced neuropathic pain
K Derangula, M Javalgekar, V Kumar Arruri… - International …, 2022 - Elsevier
Neuroinflammation is one of the most significant pathological drivers following nerve injury
which along with immune cell activation, oxidative stress and other associated molecular …
which along with immune cell activation, oxidative stress and other associated molecular …
[HTML][HTML] Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3K/AKT …
Z Cui, N Jin, FK Amevor, G Shu, X Du, X Kang, Z Ning… - Poultry Science, 2022 - Elsevier
Fatty liver hemorrhagic syndrome (FLHS) is a chronic hepatic disease which occurs when
there is a disorder in lipid metabolism. FLHS is often observed in caged laying hens and …
there is a disorder in lipid metabolism. FLHS is often observed in caged laying hens and …