Arterial blood pressure is controlled by vasodilatory factors such as nitric oxide (NO) that are
released from the endothelium under the influence of fluid shear stress exerted by flowing …

The vascular endothelium is constantly exposed to mechanical forces, including fluid shear
stress exerted by the flowing blood. Endothelial cells can sense different flow patterns and …

Early atherosclerotic lesions localize preferentially, in arterial regions exposed to low flow,
oscillatory flow, or both; however, the cellular basis of this observation remains to be …

The link between atherosclerosis and regions of disturbed flow and low wall shear stress is
now firmly established, but the causal mechanisms underlying the link are not yet …

Elevated blood pressure is a key risk factor for developing cardiovascular diseases. Blood
pressure is largely determined by vasodilatory mediators, such as nitric oxide (NO), that are …

We present a biochemical model of the wall shear stress-induced activation of endothelial
nitric oxide synthase (eNOS) in an endothelial cell. The model includes three key …

Nitric oxide is one of the major endothelial-derived vasoactive factors that regulate blood
pressure (BP), and the bioactive lipid mediator S1P (sphingosine-1-phosphate) is a potent …

Coronary artery atherosclerosis is a local, multifactorial, complex disease, and the leading
cause of death in the US. Complex interactions between biochemical transport and …

Wall shear stress (WSS) is one of the most studied hemodynamic parameters, used in
correlating blood flow to various diseases. The pulsatile nature of blood flow, along with the …

ATP is not only an energy carrier but also serves as an important signalling molecule in
many physiological processes. Abnormal ATP level in blood vessel is known to be related to …