[HTML][HTML] The physical frailty syndrome as a transition from homeostatic symphony to cacophony

LP Fried, AA Cohen, QL Xue, J Walston… - Nature aging, 2021 - nature.com
Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …

[HTML][HTML] Frailty and diabetes in older adults: Overview of current controversies and challenges in clinical practice

MZA Abd. Ghafar, M O'Donovan, D Sezgin… - Frontiers in Clinical …, 2022 - frontiersin.org
This article examines the challenges healthcare professionals face when addressing the
modern and often twin epidemics of frailty and diabetes mellitus (DM) in ageing societies …

European Respiratory Society statement on frailty in adults with chronic lung disease

CR Osadnik, LJ Brighton, C Burtin… - European …, 2023 - Eur Respiratory Soc
Frailty is a complex, multidimensional syndrome characterised by a loss of physiological
reserves that increases a person9s susceptibility to adverse health outcomes. Most …

[HTML][HTML] Frailty and potentially inappropriate prescribing in older people with polypharmacy: a bi-directional relationship?

MA Randles, D O'Mahony, PF Gallagher - Drugs & aging, 2022 - Springer
Frail older adults commonly experience multiple co-morbid illnesses and other risk factors
for potentially inappropriate prescribing. However, determination of frailty varies depending …

[HTML][HTML] Frailty and the interactions between skeletal muscle, bone, and adipose tissue-impact on cardiovascular disease and possible therapeutic measures

ME Soto, I Pérez-Torres, ME Rubio-Ruiz… - International Journal of …, 2023 - mdpi.com
Frailty is a global health problem that impacts clinical practice. It is complex, having a
physical and a cognitive component, and it is the result of many contributing factors. Frail …

[HTML][HTML] Energy metabolism and frailty: The potential role of exercise-induced myokines–A narrative review

D Barros, EA Marques, J Magalhães, J Carvalho - Ageing research reviews, 2022 - Elsevier
Frailty is a complex condition that emerges from dysregulation in multiple physiological
systems. Increasing evidence suggests the potential role of age-related energy …

[HTML][HTML] A task force for diagnosis and treatment of people with Alzheimer's disease in Latin America

F Lopera, N Custodio, M Rico-Restrepo… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) represents a substantial burden to patients, their caregivers,
health systems, and society in Latin America and the Caribbean (LAC). This impact is …

Sex-specific interventions to prevent and manage frailty

N Reid, A Young, LS Hanjani, RE Hubbard, EH Gordon - Maturitas, 2022 - Elsevier
There is growing interest in interventions that delay, slow, and even reverse frailty. In this
narrative review, we explore the evidence on exercise, nutrition, medication optimisation …

[HTML][HTML] An overview of systematic reviews and meta-analyses on the effect of medication interventions targeting polypharmacy for frail older adults

A Verma, S Saha, J Jarl, E Conlon… - Journal of Clinical …, 2023 - mdpi.com
Frailty refers to the lack of resilience and a reduction in a person's ability to recover following
a health problem, and it is increasingly becoming a challenging aspect of ageing …

Frailty and HIV: moving from characterization to intervention

KM Erlandson, DA Piggott - Current HIV/AIDS Reports, 2021 - Springer
Abstract Purpose of Review While the characteristics associated with frailty in people with
HIV (PWH) have been well described, little is known regarding interventions to slow or …