Reactive oxygen species (ROS) are short-lived and highly reactive molecules. The
generation of ROS in cells exists in equilibrium with a variety of antioxidant defences. At low …

Biochemical and genetic studies on cellular and animal models on the mechanism (s) of
action of phytochemicals provide a functional explanation of how and why a diet rich in fruits …

Type I programmed cell death (PCD) or apoptosis is critical for cellular self-destruction for a
variety of processes such as development or the prevention of oncogenic transformation …

Quercetin, a medicinally important member of the flavonoid family, is one of the most
prominent dietary antioxidants. It is present in a variety of foods—including fruits, vegetables …

Apoptosis is crucially important in mediating immune privilege of the fetus during pregnancy.
We investigated the expression and in vitro apoptotic activity of two physiologically relevant …

Increased consumption of fruit and vegetables can represent an easy strategy to significantly
reduce the incidence of cancer. We recently demonstrated that the flavonoid quercetin …

Celastrol, a plant triterpene has attracted great interest recently, especially for its potential
anti-inflammatory and anti-cancer activities. In the present report, we investigated the effect …

The interim results of the large, multinational trials on coronavirus disease 2019 (COVID‐19)
using a combination of antiviral drugs appear to have little to no effect on the 28‐day …

Fas-associated protein with death domain (FADD) is a pivotal component of death receptor-
mediated extrinsic apoptosis and necroptosis. Here we show that FADD is regulated by …

The capacity to induce tumour-cell specific apoptosis represents the most unique feature of
the TNF receptor (TNFR) family member CD40. Recent studies on the signalling events …