In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

Neuronal communication crucially relies on exocytosis of neurotransmitters from synaptic
vesicles (SVs) which are clustered at synapses. To ensure reliable neurotransmitter release …

Neuronal transmission relies on the regulated secretion of neurotransmitters, which are
packed in synaptic vesicles (SVs). Hundreds of SVs accumulate at synaptic boutons …

Coat protein complex II (COPII) plays an integral role in the packaging of secretory cargoes
within membrane-enclosed transport carriers that leave the endoplasmic reticulum (ER) from …

With an essential role in nearly every physiological process and disease state, trafficking
vesicles are fundamental to cell biology. Canonical understanding of membrane traffic has …

Secretory cargos are collected at endoplasmic reticulum (ER) exit sites (ERES) before
transport to the Golgi apparatus. Decades of research have provided many details of the …

TANGO1 protein facilitates the endoplasmic reticulum (ER) export of large cargoes that
cannot be accommodated in 60 nm transport vesicles. It assembles into a ring in the plane of …

Biomolecular condensates are cellular structures composed of membraneless assemblies
comprising proteins or nucleic acids. The formation of these condensates requires …

Phase separation of components of ER exit sites (ERES) into membraneless compartments,
the Sec bodies, occurs in Drosophila cells upon exposure to specific cellular stressors …

The heterogeneity of the endoplasmic reticulum (ER) makes it a versatile platform for a
broad range of homeostatic processes, ranging from calcium regulation to synthesis and …