Evidence-based recommendations on the clinical use of cardiopulmonary exercise testing
(CPET) in lung and heart disease are presented, with reference to the assessment of …

During exercise by healthy mammals, alveolar ventilation and alveolar‐capillary diffusion
increase in proportion to the increase in metabolic rate to prevent PaCO2 from increasing …

Previous studies of contracting muscle with low loading and partial vascular occlusion
demonstrated hypertrophy and strength adaptations similar to and exceeding those …

In health, the near-eucapnic, highly efficient hyperpnea during mild-to-moderate intensity
exercise is driven by three obligatory contributions, namely, feedforward central command …

This review examines the evidence that skeletal muscles can sense the status of the
peripheral vascular network through group III and IV muscle afferent fibers. The anatomic …

Exercise hyperpnoea is considered to be one of the major remaining challenges to
understanding the control of human systemic function. The topic is currently in an exciting …

New Findings What is the topic of this review? In this review, we examine the evidence for
control mechanisms underlying exercise hyperpnoea, giving attention to the feedback from …

Background—The overactivity of ergoreceptors (intramuscular afferents sensitive to products
of skeletal muscle work) may be responsible for the abnormal responses to exercise and …

For over a century of creative research, many theories on the possible mechanisms
controlling respiration during exercise have been developed and discussed. One of the most …

When tested in isolation, stimuli associated with respiratory CO2 exchange, feedforward
central command and type III–IV muscle afferent feedback have each been shown to be …