The cellular and molecular basis for planarian regeneration

PW Reddien - Cell, 2018 - cell.com
Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of
dramatic feats of regeneration, which have been studied for over 2 centuries. Recent …

The future of cell biology: emerging model organisms

B Goldstein, N King - Trends in cell biology, 2016 - cell.com
Most current research in cell biology uses just a handful of model systems including yeast,
Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured …

[HTML][HTML] Prospectively isolated tetraspanin+ neoblasts are adult pluripotent stem cells underlying planaria regeneration

A Zeng, H Li, L Guo, X Gao, S McKinney, Y Wang, Z Yu… - Cell, 2018 - cell.com
Proliferating cells known as neoblasts include pluripotent stem cells (PSCs) that sustain
tissue homeostasis and regeneration of lost body parts in planarians. However, the lack of …

Reading and editing the Pleurodeles waltl genome reveals novel features of tetrapod regeneration

A Elewa, H Wang, C Talavera-López, A Joven… - Nature …, 2017 - nature.com
Salamanders exhibit an extraordinary ability among vertebrates to regenerate complex body
parts. However, scarce genomic resources have limited our understanding of regeneration …

Egr-5 is a post-mitotic regulator of planarian epidermal differentiation

KC Tu, LC Cheng, H TK Vu, JJ Lange, SA McKinney… - elife, 2015 - elifesciences.org
Neoblasts are an abundant, heterogeneous population of adult stem cells (ASCs) that
facilitate the maintenance of planarian tissues and organs, providing a powerful system to …

Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano

K Wasik, J Gurtowski, X Zhou… - Proceedings of the …, 2015 - National Acad Sciences
The free-living flatworm, Macrostomum lignano has an impressive regenerative capacity.
Following injury, it can regenerate almost an entirely new organism because of the presence …

Harnessing the stem cell niche in regenerative medicine: innovative avenue to combat neurodegenerative diseases

G Velikic, DM Maric, DL Maric, G Supic… - International journal of …, 2024 - mdpi.com
Regenerative medicine harnesses the body's innate capacity for self-repair to restore
malfunctioning tissues and organs. Stem cell therapies represent a key regenerative …

An insight into planarian regeneration

XY Ge, X Han, YL Zhao, GS Cui, YG Yang - Cell Proliferation, 2022 - Wiley Online Library
Background Planarian has attracted increasing attentions in the regeneration field for its
usefulness as an important biological model organism attributing to its strong regeneration …

Cell-type diversity and regionalized gene expression in the planarian intestine

DJ Forsthoefel, NI Cejda, UW Khan, PA Newmark - Elife, 2020 - elifesciences.org
Proper function and repair of the digestive system are vital to most animals. Deciphering the
mechanisms involved in these processes requires an atlas of gene expression and cell …

[HTML][HTML] Homeostatic and regenerative neurogenesis in salamanders

A Joven, A Simon - Progress in neurobiology, 2018 - Elsevier
Large-scale regeneration in the adult central nervous system is a unique capacity of
salamanders among tetrapods. Salamanders can replace neuronal populations, repair …