X-ray scattering studies of protein structural dynamics
X-ray scattering is uniquely suited to the study of disordered systems and thus has the
potential to provide insight into dynamic processes where diffraction methods fail. In …
potential to provide insight into dynamic processes where diffraction methods fail. In …
The entry reaction of the plant shikimate pathway is subjected to highly complex metabolite-mediated regulation
R Yokoyama, MVV de Oliveira, B Kleven… - The Plant …, 2021 - academic.oup.com
The plant shikimate pathway directs bulk carbon flow toward biosynthesis of aromatic amino
acids (AAAs, ie tyrosine, phenylalanine, and tryptophan) and numerous aromatic …
acids (AAAs, ie tyrosine, phenylalanine, and tryptophan) and numerous aromatic …
Why is manganese so valuable to bacterial pathogens?
J Čapek, B Večerek - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
Apart from oxygenic photosynthesis, the extent of manganese utilization in bacteria varies
from species to species and also appears to depend on external conditions. This …
from species to species and also appears to depend on external conditions. This …
Mechanistic investigation of a D to N mutation in DAHP synthase that dictates carbon flux into the shikimate pathway in yeast
H Liu, Q Xiao, X Wu, H Ma, J Li, X Guo, Z Liu… - Communications …, 2023 - nature.com
deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) is a key enzyme in the
shikimate pathway for the biosynthesis of aromatic compounds. L-Phe and L-Tyr bind to the …
shikimate pathway for the biosynthesis of aromatic compounds. L-Phe and L-Tyr bind to the …
An in-silico approach to unravel the structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHPS): a critical enzyme for sennoside biosynthesis in …
The laxative properties of senna are attributed to the presence of sennosides produced in
the plant. The low production level of sennosides in the plant is an important impediment to …
the plant. The low production level of sennosides in the plant is an important impediment to …
Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-d-arabino-heptulosonate …
In Pseudomonas aeruginosa (Pae), the shikimate pathway end product, chorismate, serves
as the last common precursor for the biosynthesis of both primary aromatic metabolites …
as the last common precursor for the biosynthesis of both primary aromatic metabolites …
Structural and biochemical analyses reveal quinic acid inhibits DAHP synthase a key player in shikimate pathway
K Jangid, JK Mahto, KA Kumar, P Dhaka… - Archives of Biochemistry …, 2025 - Elsevier
The shikimate pathway, essential for aromatic amino acid biosynthesis, is absent in animals,
making its enzymes promising targets for developing antimicrobials. 3-Deoxy-D-arabino …
making its enzymes promising targets for developing antimicrobials. 3-Deoxy-D-arabino …
Diverse allosteric componentry and mechanisms control entry into aromatic metabolite biosynthesis
Highlights•DAH7PS is first enzyme of aromatic compound biosynthesis.•Allosteric regulation
of DAH7PS is important for metabolic control.•DAH7PS enzymes share a common catalytic …
of DAH7PS is important for metabolic control.•DAH7PS enzymes share a common catalytic …
Calculated pKa Variations Expose Dynamic Allosteric Communication Networks
EJM Lang, LC Heyes, GB Jameson… - Journal of the American …, 2016 - ACS Publications
Allosteric regulation of protein function, the process by which binding of an effector molecule
provokes a functional response from a distal site, is critical for metabolic pathways. Yet, the …
provokes a functional response from a distal site, is critical for metabolic pathways. Yet, the …
Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis
The first enzyme of the shikimate pathway, 3-deoxy-D-arabino-heptulosonate 7-phosphate
synthase (DAH7PS), adopts a range of distinct allosteric regulation mechanisms in different …
synthase (DAH7PS), adopts a range of distinct allosteric regulation mechanisms in different …