The role of three-dimensional in vitro models in modelling the inflammatory microenvironment associated with obesity in breast cancer
Obesity is an established risk factor for breast cancer in postmenopausal women. However,
the underlying biological mechanisms of how obesity contributes to breast cancer remains …
the underlying biological mechanisms of how obesity contributes to breast cancer remains …
Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome
Environmental chemicals such as bisphenol A (BPA) are thought to contribute to
carcinogenesis through their endocrine-disrupting properties. Due to accumulating evidence …
carcinogenesis through their endocrine-disrupting properties. Due to accumulating evidence …
Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution
The rise and fall of estrogen and progesterone across menstrual cycles and during
pregnancy regulates breast development and modifies cancer risk. How these hormones …
pregnancy regulates breast development and modifies cancer risk. How these hormones …
A novel preclinical model of the normal human breast
AJ Wilby, S Cabral, N Zoghi, SJ Howell… - Journal of Mammary …, 2024 - Springer
Improved screening and treatment have decreased breast cancer mortality, although
incidence continues to rise. Women at increased risk of breast cancer can be offered risk …
incidence continues to rise. Women at increased risk of breast cancer can be offered risk …
Antibody validation for estrogen receptor beta
Antibodies can cross-react with proteins other than their intended targets, and antibody-
based applications can, if not properly validated, lead to flawed interpretations. When …
based applications can, if not properly validated, lead to flawed interpretations. When …
Comparison of hormone-induced mRNA and protein biomarker expression changes in breast cancer cells
SM Bernhardt, P Dasari, DJ Glynn… - Breast Cancer Research …, 2021 - Springer
Purpose Protein biomarkers estrogen receptor (ER), progesterone receptor (PR), and
marker of proliferation (Ki67) are routinely assessed by immunohistochemistry to guide …
marker of proliferation (Ki67) are routinely assessed by immunohistochemistry to guide …
Generalizable machine learning methods for network inference in systems biology
G Rabadam - 2024 - escholarship.org
Tissues comprise a multiplicity of specialized cell types that must coordinate state changes
in order to function collectively. These state changes are orchestrated by coordinated direct …
in order to function collectively. These state changes are orchestrated by coordinated direct …
Mapping the complex paracrine response to hormones in the human breast at single-cell resolution
The rise and fall of estrogen and progesterone across menstrual cycles and during
pregnancy controls breast development and modifies cancer risk. How these hormones …
pregnancy controls breast development and modifies cancer risk. How these hormones …
MECHANISM OF DNA DAMAGE ASSOSCIATED WITH ESTROGEN RECEPTOR ALPHA–INTERPLAY OF NON-CANONICAL DNA SECONDARY STRUCTURES
A SHARMA - 2021 - scholarworks.umass.edu
Breast cancer is the second leading cause of cancer mortality among women. Many risk
factors for breast cancer are related to estrogen exposure and high serum estrogen levels …
factors for breast cancer are related to estrogen exposure and high serum estrogen levels …
[PDF][PDF] Variation in DNA Repair Mechanisms Can Influence Effects of Oestrogen and Environmental Chemicals on Breast Cancer Susceptibility
DJ Jerry - scientia.global
At some point in their lifetime, 1 in 8 women in the USA will be diagnosed with breast cancer.
Genetic factors and exposure to endogenous (ie, internal) and environmental hormones can …
Genetic factors and exposure to endogenous (ie, internal) and environmental hormones can …