Diabetic retinopathy (DR), a microvascular complication of diabetes mellitus (DM), remains
as one of the major causes of vision loss worldwide. The release of pro-inflammatory …

Diabetic macular edema is a major cause of visual impairment. The pathogenesis of
macular edema appears to be multifactorial. Laser photocoagulation is the standard of care …

Oxygen metabolism is essential for sustaining aerobic life, and normal cellular homeostasis
works on a fine balance between the formation and elimination of reactive oxygen species …

Advanced glycation end products (AGEs) are linked with the development of diabetic
retinopathy; however, the pathogenic mechanisms are poorly defined. Vascular endothelial …

Diabetes mellitus is associated with a 5‐fold higher prevalence of cataracts, which remains
a major cause of blindness in the world. Typical diabetic cataracts contain cortical and/or …

Aberrant blood vessel growth in the retina that underlies the pathology of proliferative
diabetic retinopathy and retinopathy of prematurity is the result of the ischemia-driven …

The 2-oxoaldehyde methylglyoxal (MeG) is the precursor to a number of the known
advanced glycation endproducts (AGE) implicated in the development of diabetic …

Hyperglycemia, glycoxidation and receptor for advanced glycation endproducts: potential
mechanisms underlying diabetic complicat Page 1 Periodontology 2000, Vol. 23, 2000, 50–62 …

purpose. To examine the relationship between early retinal capillary cell apoptosis and late
histologic lesions of diabetic retinopathy and to compare the effects of aminoguanidine …

The study addressed the role for aldose reductase (AR) in 1) retinal oxidative stress and
vascular endothelial growth factor (VEGF) overexpression in early diabetes, and 2) high …