Helminth infections and host immune regulation
HJ McSorley, RM Maizels - Clinical microbiology reviews, 2012 - Am Soc Microbiol
Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …
regions. However, regions where helminth parasites are endemic record much lower …
Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases
J Alvar, F Alves, B Bucheton, L Burrows… - Seminars in …, 2020 - Springer
Progress has been made in the control or elimination of tropical diseases, with a significant
reduction of incidence. However, there is a risk of re-emergence if the factors fueling …
reduction of incidence. However, there is a risk of re-emergence if the factors fueling …
Epilepsy and nodding syndrome in association with an Onchocerca volvulus infection drive distinct immune profile patterns
K Arndts, J Kegele, AS Massarani, M Ritter… - PLOS Neglected …, 2023 - journals.plos.org
Previous studies have described the association of onchocerciasis (caused by Onchocerca
volvulus) with epilepsy, including nodding syndrome, although a clear etiological link is still …
volvulus) with epilepsy, including nodding syndrome, although a clear etiological link is still …
Helminth antigens differentially modulate the activation of CD4+ and CD8+ T lymphocytes of convalescent COVID-19 patients in vitro
Background The coronavirus disease 2019 (COVID-19) is a respiratory disease caused by
SARS-CoV-2, a recently discovered strain of coronavirus. The virus has spread rapidly …
SARS-CoV-2, a recently discovered strain of coronavirus. The virus has spread rapidly …
Comparison of doxycycline, minocycline, doxycycline plus albendazole and albendazole alone in their efficacy against onchocerciasis in a randomized, open-label …
U Klarmann-Schulz, S Specht, AY Debrah… - PLoS neglected …, 2017 - journals.plos.org
The search for new macrofilaricidal drugs against onchocerciasis that can be administered
in shorter regimens than required for doxycycline (DOX, 200mg/d given for 4–6 weeks) …
in shorter regimens than required for doxycycline (DOX, 200mg/d given for 4–6 weeks) …
Wuchereria bancrofti-infected individuals harbor distinct IL-10-producing regulatory B and T cell subsets which are affected by anti-filarial treatment
Despite worldwide mass drug administration, it is estimated that 68 million individuals are
still infected with lymphatic filariasis with 19 million hydrocele and 17 million lymphedema …
still infected with lymphatic filariasis with 19 million hydrocele and 17 million lymphedema …
Mansonella perstans microfilaremic individuals are characterized by enhanced type 2 helper T and regulatory T and B cell subsets and dampened systemic innate …
M Ritter, WPC Ndongmo, AJ Njouendou… - PLoS neglected …, 2018 - journals.plos.org
The filarial nematode Mansonella perstans is endemic throughout Africa, northern South
America and the Caribbean. Interestingly, M. perstans-infected individuals present no …
America and the Caribbean. Interestingly, M. perstans-infected individuals present no …
Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages
Helminths immunomodulate their hosts and induce a regulatory, anti-inflammatory milieu
that prevents allergies and autoimmune diseases. Helminth immunomodulation may benefit …
that prevents allergies and autoimmune diseases. Helminth immunomodulation may benefit …
In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae
MP Hübner, M Koschel, D Struever… - PLoS neglected …, 2019 - journals.plos.org
Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4–6 weeks of
doxycycline treatment can lead to permanent sterilization and adult filarial death. We …
doxycycline treatment can lead to permanent sterilization and adult filarial death. We …
Helminths and their implication in sepsis–a new branch of their immunomodulatory behaviour?
The prevalence of autoimmune and allergic disorders has dramatically increased in
developed countries, and it is believed that our 'cleaner living'reduces exposure to certain …
developed countries, and it is believed that our 'cleaner living'reduces exposure to certain …