Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

Therapy of invasive infections due to multidrug-resistant Enterobacteriaceae (MDR-E) is
challenging, and some of the few active drugs are not available in many countries. For …

Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …

Infections of antibiotic-resistant pathogens pose an ever-increasing threat to mankind. The
investigation of novel approaches for tackling the antimicrobial resistance crisis must be part …

In this review, we summarize the current “state of the art” of carbapenem antibiotics and their
role in our antimicrobial armamentarium. Among the β-lactams currently available …

CTX-M β-lactamases are considered a paradigm in the evolution of a resistance
mechanism. Incorporation of different chromosomal bla CTX-M related genes from different …

Gram-negative bacteria are responsible for a large proportion of antibiotic-resistant bacterial
diseases. These bacteria have a complex cell envelope that comprises an outer membrane …

Antibiotic resistance is now a linked global problem. Dispersion of successful clones of
multidrug resistant (MDR) bacteria is common, often via the movement of people. Local …

OmpK35 and OmpK36 are the major outer membrane porins of Klebsiella pneumoniae. In
this study, a virulent clinical isolate was selected to study the role of these two porins in …

Since antibiotic resistance usually affords a gain of function, there is an associated
biological cost resulting in a loss of fitness of the bacterial host. Considering that antibiotic …