The lactic acid bacteria (LAB) are essential for food fermentations and their impact on gut
physiology and health is under active exploration. In addition to their well-studied …

For prototrophic bacteria, central metabolism (ie, glycolysis, the pentose phosphate
pathway, and the Krebs cycle) supplies the 13 biosynthetic intermediates necessary to …

The resistance and immune escape of methicillin-resistant Staphylococcus aureus (MRSA)
biofilms cause recalcitrant infections. Here, we design a targeting and synergizing cascade …

Staphylococcus aureus must rapidly adapt to a variety of carbon and nitrogen sources
during invasion of a host. Within a staphylococcal abscess, preferred carbon sources such …

The catabolite control protein CcpA is a pleiotropic regulator that mediates the global
transcriptional response to rapidly catabolizable carbohydrates, like glucose in Gram …

Neutrophils are indispensable for clearing infections with the prominent human pathogen
Staphylococcus aureus. Here, we report that S. aureus secretes a family of proteins that …

Staphylococcus aureus causes acute and chronic infections resulting in significant
morbidity. Urease, an enzyme that generates NH3 and CO2 from urea, is key to pH …

The phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a carbohydrate
transport and phosphorylation system present in bacteria of all different phyla and in …

The surge of antibiotic resistance in Staphylococcus aureus calls for novel drugs that attack
new targets. Developing antimicrobial peptides (AMPs) or antivirulence agents (AvAs) is a …

Metabolomics is a mainstream approach for investigating the metabolic underpinnings of
complex biological phenomena and is increasingly being applied to large-scale studies …