Obesity is a major health problem strongly increasing the risk for various severe related
complications such as metabolic syndrome, cardiovascular diseases, respiratory disorders …

The worldwide epidemic of obesity has brought considerable attention to research aimed at
understanding the biology of adipocytes (fat cells) and the events occurring in adipose …

A growing body of evidence indicates that obesity is strongly and independently associated
with adverse outcomes of COVID-19, including death. By combining emerging knowledge of …

The global epidemic of obesity is accompanied by an increased prevalence of
cardiovascular disease (CVD), in particular stroke and heart attack. Dysfunctional adipose …

Obesity is a prevalent global public health issue characterized by excess body fat. Adipose
tissue is now recognized as an important endocrine organ releasing an abundance of …

After more than two decades of research into phosphodiesterase 4 (PDE4) inhibitors,
roflumilast (3-cyclopropylmethoxy-4-difluoromethoxy-N-[3, 5-di-chloropyrid-4-yl]-benzamide) …

Obesity-related disorders, such as insulin resistance, hypertension and atherosclerosis, are
associated with chronic inflammation. Adiponectin is an adipocyte-derived secreted factor …

Purpose of Review A growing body of evidence suggests that obesity and increased visceral
adiposity are strongly and independently linked to adverse outcomes and death due to …

Systemic sclerosis (SSc) is characterized by vascular alterations, activation of the immune
system and tissue fibrosis. Vascular insufficiency manifests early in the disease, and …

Fibrosis is the final path of nearly every form of chronic disease, regardless of the
pathogenesis. Upon chronic injury, activated, fibrogenic fibroblasts deposit excess …