Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …

Cancer invasion and the ability of malignant tumor cells for directed migration and
metastasis have remained a focus of research for many years. Numerous studies have …

Pore-forming toxins (PFTs) are key virulence determinants produced and secreted by a
variety of human bacterial pathogens. They disrupt the plasma membrane (PM) by …

Drosophila melanogaster has been extensively used to study the humoral arm of innate
immunity because of the developmental and functional parallels with mammalian innate …

Strain and physical trauma to mechanically active cells, such as skeletal muscle myofibers,
injures their plasma membranes, and mitochondrial function is required for their repair. We …

Throughout development, tissues undergo complex morphological changes, resulting from
cellular mechanics that evolve over time and in three-dimensional space. During Drosophila …

The closure of gaps is crucial to maintaining epithelium integrity during developmental and
repair processes such as dorsal closure and wound healing. Depending on biochemical as …

Closure of wounds and gaps in tissues is fundamental for the correct development and
physiology of multicellular organisms and, when misregulated, may lead to inflammation …

α-Catenin couples the cadherin–catenin complex to the actin cytoskeleton. The
mechanosensitive α-Catenin M region undergoes conformational changes upon application …

Re-epithelialization of cutaneous wounds in adult mammals takes days to complete and
relies on numerous signalling cues and multiple overlapping cellular processes that take …