Mass spectrometry (MS) is a powerful tool to analyze complex mixtures of proteins in a high‐
throughput fashion. Proteome analysis has already become a routine task in biomedical …

Somewhat counterintuitively, the tyrosine phosphatase SHP-2 (SH2 domain-containing
protein tyrosine phosphatase-2) is crucial for the activation of extracellular signal-regulated …

Background Type 2 innate lymphoid cells (ILC2s) represent an important type 2 immune
cell. Glucocorticoid regulation of human ILC2s is largely unknown. Objective We sought to …

Adults and children with high-risk CRLF2-rearranged acute lymphoblastic leukemia (ALL)
respond poorly to current cytotoxic chemotherapy and suffer unacceptably high rates of …

Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role
in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP …

Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk
ALL commonly associated with alterations that affect the tyrosine kinase pathway, tumor …

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk
ALL subtype with high rates of relapse and poor patient outcome. Activating mutations …

Protein phosphorylation is one of the most common post-translational modifications used in
signal transduction to control cell growth, proliferation, and survival in response to both …

Background Cytokine receptor-like factor 2 (CRLF2) is a subunit of the receptor for thymic
stromal lymphopoietin (TSLP). A somatic mutation (insEIM) in the transmembrane domains …

Children and adults with Philadelphia chromosome–like B cell acute lymphoblastic
leukemia (Ph-like B-ALL) experience high relapse rates despite best-available conventional …