1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …

Abstract Phospholipase A 2 (PLA 2) enzymes are the upstream regulators of the eicosanoid
pathway liberating free arachidonic acid from the sn-2 position of membrane phospholipids …

A metal‐free visible‐light‐induced cyclization procedure was developed for the rapid
synthesis of perfluoroalkyl‐substituted benzimidazo [2, 1‐a] isoquinolin‐6 (5H)‐ones and …

Availability of free arachidonic acid (AA) constitutes a rate limiting factor for cellular
eicosanoid synthesis. AA distributes differentially across membrane phospholipids, which is …

Phospholipase A 2 s generate lipid mediators that constitute an important component of the
integrated response of macrophages to stimuli of the innate immune response. Because …

Fluorinated compounds attracted remarkable interest in recent decades. 1 Unique complex
of physicochemical and biological properties provided by incorporation of fluorine or …

Phospholipases A2 (PLA2) are a diverse group of enzymes that hydrolyze membrane
phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is metabolized …

Macrophages contain large amounts of arachidonic acid (AA), which distributes differentially
across membrane phospholipids. This is largely due to the action of coenzyme A …

Abstract Phospholipase A 2 (PLA 2) enzymes are involved in various inflammatory
pathological conditions including arthritis, cardiovascular and autoimmune diseases. The …