Dissecting how CD4 T cells are lost during HIV infection
Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail,
less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is …
less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is …
DNA sensing in the innate immune response
The innate immune system recognizes conserved pathogen-associated molecular patterns
and produces inflammatory cytokines that direct downstream immune responses. The …
and produces inflammatory cytokines that direct downstream immune responses. The …
IFI16 is an innate immune sensor for intracellular DNA
L Unterholzner, SE Keating, M Baran, KA Horan… - Nature …, 2010 - nature.com
The detection of intracellular microbial DNA is critical to appropriate innate immune
responses; however, knowledge of how such DNA is sensed is limited. Here we identify …
responses; however, knowledge of how such DNA is sensed is limited. Here we identify …
Recognition of herpesviruses by the innate immune system
SR Paludan, AG Bowie, KA Horan… - Nature Reviews …, 2011 - nature.com
Advances in innate immunity over the past decade have revealed distinct classes of pattern
recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular …
recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular …
Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16
T Li, BA Diner, J Chen… - Proceedings of the …, 2012 - National Acad Sciences
Detection of pathogenic nucleic acids is essential for mammalian innate immunity. IFN-
inducible protein IFI16 has emerged as a critical sensor for detecting pathogenic DNA …
inducible protein IFI16 has emerged as a critical sensor for detecting pathogenic DNA …
Molecular and structural basis of DNA sensors in antiviral innate immunity
DNA viruses are a source of great morbidity and mortality throughout the world by causing
many diseases; thus, we need substantial knowledge regarding viral pathogenesis and the …
many diseases; thus, we need substantial knowledge regarding viral pathogenesis and the …
Innate sensing of DNA virus genomes
DNA viruses are linked to many infectious diseases and contribute significantly to human
morbidity and mortality worldwide. Moreover, DNA viral infections are usually lifelong and …
morbidity and mortality worldwide. Moreover, DNA viral infections are usually lifelong and …
The PYHIN protein family as mediators of host defenses
SA Schattgen, KA Fitzgerald - Immunological reviews, 2011 - Wiley Online Library
The innate immune response is the first line of defense against infection and relies on the
ability of immune cells to detect the presence of infection through germline‐encoded pattern …
ability of immune cells to detect the presence of infection through germline‐encoded pattern …
Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy
SR Morrone, T Wang… - Proceedings of the …, 2014 - National Acad Sciences
Whether host DNA receptors have any capacity to distinguish self from nonself at the
molecular level is an outstanding question in the innate immunity of mammals. Here, by …
molecular level is an outstanding question in the innate immunity of mammals. Here, by …
Biochemical regulation of the inflammasome
JK Dowling, LAJ O'Neill - Critical reviews in biochemistry and …, 2012 - Taylor & Francis
The extensively studied cytokine IL-1β is an important mediator of the inflammatory
response. However, dysregulated release of IL-1β can be detrimental and is attributed to the …
response. However, dysregulated release of IL-1β can be detrimental and is attributed to the …