The origins of low-temperature tissue storage research date back to the late 1800s. Over half
a century later, osmotic stress was revealed to be a main contributor to cell death during …

Context Male infertility is defined as the inability to conceive following 1 year of regular
unprotected intercourse. It is the causative factor in 50% of couples and a leading indication …

Mitochondria, fundamental organelles in cell metabolism, and ATP synthesis are
responsible for generating reactive oxygen species (ROS), calcium homeostasis, and cell …

BACKGROUND Infertility affects∼ 7% of all men. Despite much progress, mainly in
genetics, its etiology remains obscure in∼ 50% of cases. To fill this gap, imaging of the male …

Reactive oxygen species (ROS) generated at low levels during mitochondrial respiration
have key roles in several signaling pathways. Oxidative stress (OS) arises when the …

Cryopreservation is an expanding strategy to allow not only fertility preservation for
individuals who need such procedures because of gonadotoxic treatments, active duty in …

Background Except for testicular cancer and Hodgkin's disease, baseline data on semen
quality in case of cancers as well as systemic pathologies of the young adult are scarce or …

Survival rates for children and adolescents diagnosed with malignancy have been steadily
increasing due to advances in oncology treatments. These treatments can have a toxic effect …

Sperm cryopreservation has been utilized routinely for over 40 years to preserve fertility in
men undergoing cancer therapy and allow conception for infertile couples. This article …

Cancer impairs spermatogenesis, whereas results on sperm DNA integrity are controversial
and no data are available about sperm oxidative stress. In cancer patients, we detected …