Transposable elements are abundant in the human genome, and great strides have been
made in pinpointing variations in these repetitive sequences using whole-genome …

Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event
is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in …

AZD6738 (ceralasertib) is a potent and selective orally bioavailable inhibitor of ataxia
telangiectasia and Rad3-related (ATR) kinase. ATR is activated in response to stalled DNA …

Amplification of MYCN is the driving oncogenic change in a subset of high-risk
neuroblastomas. The MYCN protein and the Aurora-A kinase form a complex during the S …

Sulfonimidoyl halides have previously shown poor stability and selectivity in reaction with
organometallic reagents. Here we report the preparation of enantioenriched sulfonimidoyl …

New route development activities toward ceralasertib (AZD6738) have resulted in the
discovery of an efficient, acid additive-free, photoredox Minisci reaction. Mechanistic …

The development of NH transfer reactions using hypervalent iodine and simple sources of
ammonia has facilitated the synthesis of sulfoximines and sulfonimidamides for applications …

Inhibition of ribonucleotide reductase (RNR), the rate-limiting enzyme in the synthesis of
deoxyribonucleotides, causes DNA replication stress and activates the ataxia telangiectasia …

The discovery of new, active DNA transposons can expand the range of genetic tools and
provide more options for genomic manipulation. In this study, a bioinformatics analysis …

Genomic rearrangements are a hallmark of most childhood tumors, including
medulloblastoma, one of the most common brain tumors in children, but their causes remain …