Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor
prognosis and limited therapeutic options. Research on the tumor microenvironment (TME) …

Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …

Acute pancreatitis (AP) is one of the most common inflammatory diseases of the
gastrointestinal tract and a steady rising diagnosis for inpatient hospitalization. About one in …

Background Epithelial remodeling is a prominent feature of eosinophilic chronic
rhinosinusitis with nasal polyps (eCRSwNP), and infiltration of M2 macrophages plays a …

Introduction The NLRP3 inflammasome has been implicated in the initiation of inflammation
and tumorigenesis; however, its role in epithelial ovarian cancer (EOC) remains unclear …

We conducted a phase I trial to determine the optimal dose of triplet therapy with the tyrosine
kinase inhibitor sitravatinib plus nivolumab plus ipilimumab in 22 previously untreated …

Macrophages are myeloid cells that receive, integrate, and respond to tumoral cues. Tumors
evolve and are shaped by macrophages, with tumor-associated macrophage (TAM)-tumor …

Cancer is a progressive disease that can develop and evolve over decades, with
inflammation playing a central role at each of its stages, from tumor initiation to metastasis. In …

Tissue-resident macrophages (TRMs) are abundant immune cells within pre-metastatic
sites, yet their functional contributions to metastasis remain incompletely understood. Here …