Simple Summary The unfolded protein response (UPR) is the cells' way of maintaining the
balance of protein folding in the endoplasmic reticulum, which is the section of the cell …

The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …

Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.
Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute …

Scap is a polytopic membrane protein that functions as a molecular machine to control the
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …

Gene transcription and cell metabolism are two fundamental biological processes that
mutually regulate each other. Upregulated or altered expression of glucose metabolic genes …

Cholesterol is an essential component for neuronal physiology not only during development
stage but also in the adult life. Cholesterol metabolism in brain is independent from that in …

Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …

Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound
transcription factors that activate genes encoding enzymes required for synthesis of …

Abstract Background Phosphoenolpyruvate Carboxykinase (PCK) has been almost
exclusively recognized as a critical enzyme in gluconeogenesis, especially in liver and …

ATF6 is a membrane-bound transcription factor that activates genes in the endoplasmic
reticulum (ER) stress response. When unfolded proteins accumulate in the ER, ATF6 is …