Abstract The TGF beta-1,-2 and-3 isoforms are transcribed from different genes but bind to
the same receptors and signal through the same canonical and non-canonical signal …

The fibrotic diseases encompass a wide spectrum of entities including such multisystemic
diseases as systemic sclerosis, nephrogenic systemic fibrosis and sclerodermatous graft …

The advancement of microRNA (miRNA) therapies has been hampered by difficulties in
delivering miRNA to the injured kidney in a robust and sustainable manner. Using …

MicroRNAs (miRNAs) are short non-coding RNA species which are important post-
transcriptional regulators of gene expression and play an important role in the pathogenesis …

The cytokine transforming growth factor (TGF)-β1 plays a central role in diabetic
nephropathy (DN) with data implicating the miRNA (miR) miR-21 as a key modulator of its …

Micro (mi) RNAs are frequently dysregulated in the development of renal fibrosis. Exosomes
are small membrane vesicles that could be isolated from urine secreted from all nephron …

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause
of renal failure. Here we identify miR-17 as a target for the treatment of ADPKD. We report …

Several studies have suggested that extracellular vesicles (EVs) released from
mesenchymal stem cells (MSCs) may mediate MSC paracrine action on kidney …

A significant body of evidence supports the protective role of exercise training (ET) in
cardiovascular diseases, skeletal muscle dystrophies, several types of cancer, Alzheimer …

Renal fibrosis induced by urinary tract obstruction is a common clinical occurrence;
however, effective treatment is lacking, and a deeper understanding of the mechanism of …