Physical activity, by definition, is any skeletal muscle body movement that results in energy
expenditure. In the last few decades, a plethora of scientific evidences have accumulated …

Introduction: Cannabis has been used for medical purposes across the world for centuries.
As states and countries implement medical and recreational cannabis policies, increasing …

Background A proposed mechanism of chronic pain is dysregulation between the main
inhibitory (GABA) and excitatory (glutamate) neurometabolites of the central nervous system …

Musculoskeletal conditions are the leading cause of disability worldwide and also have a
large impact on many other aspects of older people's health such as low physical activity …

Chronic pain is often measured with a severity score that overlooks its spatial distribution
across the body. This widespread pain is believed to be a marker of centralization, a central …

Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved for the treatment of
patients affected by major depressive disorder (MDD), generalized anxiety disorder (GAD) …

Background Pain from various locations in the body and mental illness are common and the
comorbidity between the two is well‐known although the temporal relationship remains to be …

The heterogeneity of the clinical presentation and the pathophysiologic mechanisms
associated with fibromyalgia (FM), and the modest results on average for any therapy, call …

Chronic pain associated with fibromyalgia (FM) affects a large portion of the population but
the underlying mechanisms leading to this altered pain are still poorly understood. Evidence …

For centuries, cannabis has been used with many different purposes, including medicinal
use, usually bypassing any formal approval process. However, during the last decade …