Abstract Objectives/Hypothesis Proteins p53 and cyclin D1 play a crucial role in cell cycle
control. Protein p53 mutations are one of the most common genetic alterations in human …

Research advances over the past decade have led to a changing perception of the natural
history of head and neck cancer. For instance, we now have the capacity to quantify and …

Conclusion. Contrary to most reports, our study shows that the expression of cyclin D1 is not
an independent prognostic factor in patients with laryngeal cancer (LC). No correlation …

Materials and Methods The analysis was carried out with a set of 217 patients suffering from
HNSCC treated at the Clinic of Otorhinolaryngology and Head and Neck Surgery in Brno …

‘Risky’ epithelium in the larynx – a practical diagnosis? Page 1 COMMENTARY ‘Risky’
epithelium in the larynx – a practical diagnosis? TR Helliwell Department of Pathology …

Squamous cell carcinoma of the pharynx and larynx (SCCPL) is a genetically complex
disease and is frequently associated with nonrandom chromosomal alterations. Fifty primary …

Cervical intraepithelial neoplasia grade 3 (CIN 3) is considered a high-risk precursor of
invasive cervical cancer. alpha-Difluoromethylornithine (DFMO) is a promising …

Concurrent DNA flow cytometric (FCM) and fluorescence in situ hybridization (FISH)
analyses were prospectively performed on 24 primary untreated head and neck squamous …

Numerous malignant neoplasias are found to contain varying proportions of high-ploidy
cells. Although the role they play in the tumor is poorly understood, several lines of evidence …

Although cell polyploidization is not an infrequent event in mammalian cells and is common
in tumours, the mechanisms involved are not well understood. Using the murine B16 cell …