Advances in predicting subcellular localization of multi-label proteins and its implication for developing multi-target drugs
KC Chou - Current medicinal chemistry, 2019 - ingentaconnect.com
The smallest unit of life is a cell, which contains numerous protein molecules. Most of the
functions critical to the cell's survival are performed by these proteins located in its different …
functions critical to the cell's survival are performed by these proteins located in its different …
Progresses in predicting post-translational modification
KC Chou - International Journal of Peptide Research and …, 2020 - Springer
Identification of the sites of post-translational modifications (PTMs) in protein, RNA, and DNA
sequences is currently a very hot topic. This is because the information thus obtained is very …
sequences is currently a very hot topic. This is because the information thus obtained is very …
[HTML][HTML] iDNA6mA-PseKNC: Identifying DNA N6-methyladenosine sites by incorporating nucleotide physicochemical properties into PseKNC
Abstract N 6-methyladenine (6mA) is one kind of post-replication modification (PTM or
PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will …
PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will …
iPromoter-2L: a two-layer predictor for identifying promoters and their types by multi-window-based PseKNC
B Liu, F Yang, DS Huang, KC Chou - Bioinformatics, 2018 - academic.oup.com
Motivation Being responsible for initiating transaction of a particular gene in genome,
promoter is a short region of DNA. Promoters have various types with different functions …
promoter is a short region of DNA. Promoters have various types with different functions …
[HTML][HTML] 2L-piRNA: a two-layer ensemble classifier for identifying piwi-interacting RNAs and their function
B Liu, F Yang, KC Chou - Molecular Therapy-Nucleic Acids, 2017 - cell.com
Involved with important cellular or gene functions and implicated with many kinds of cancers,
piRNAs, or piwi-interacting RNAs, are of small non-coding RNA with around 19–33 nt in …
piRNAs, or piwi-interacting RNAs, are of small non-coding RNA with around 19–33 nt in …
[HTML][HTML] pLoc-mEuk: Predict subcellular localization of multi-label eukaryotic proteins by extracting the key GO information into general PseAAC
X Cheng, X Xiao, KC Chou - Genomics, 2018 - Elsevier
Many efforts have been made in predicting the subcellular localization of eukaryotic
proteins, but most of the existing methods have the following two limitations:(1) their …
proteins, but most of the existing methods have the following two limitations:(1) their …
iEnhancer-EL: identifying enhancers and their strength with ensemble learning approach
B Liu, K Li, DS Huang, KC Chou - Bioinformatics, 2018 - academic.oup.com
Motivation Identification of enhancers and their strength is important because they play a
critical role in controlling gene expression. Although some bioinformatics tools were …
critical role in controlling gene expression. Although some bioinformatics tools were …
iRNA (m6A)-PseDNC: identifying N6-methyladenosine sites using pseudo dinucleotide composition
As a prevalent post-transcriptional modification, N 6-methyladenosine (m 6 A) plays key
roles in a series of biological processes. Although experimental technologies have been …
roles in a series of biological processes. Although experimental technologies have been …
[HTML][HTML] Pse-in-One 2.0: an improved package of web servers for generating various modes of pseudo components of DNA, RNA, and protein sequences
B Liu, H Wu, KC Chou - Natural science, 2017 - scirp.org
Pse-in-One 2.0 is a package of web-servers evolved from Pse-in-One (Liu, B., Liu, F., Wang,
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …
pLoc-mPlant: predict subcellular localization of multi-location plant proteins by incorporating the optimal GO information into general PseAAC
X Cheng, X Xiao, KC Chou - Molecular BioSystems, 2017 - pubs.rsc.org
One of the fundamental goals in cellular biochemistry is to identify the functions of proteins in
the context of compartments that organize them in the cellular environment. To realize this, it …
the context of compartments that organize them in the cellular environment. To realize this, it …