Brain network communication: concepts, models and applications

C Seguin, O Sporns, A Zalesky - Nature reviews neuroscience, 2023 - nature.com
Understanding communication and information processing in nervous systems is a central
goal of neuroscience. Over the past two decades, advances in connectomics and network …

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

F Leng, P Edison - Nature Reviews Neurology, 2021 - nature.com
Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

Frontotemporal lobar degeneration

M Grossman, WW Seeley, AL Boxer, AE Hillis… - Nature Reviews …, 2023 - nature.com
Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …

The human connectome in Alzheimer disease—relationship to biomarkers and genetics

M Yu, O Sporns, AJ Saykin - Nature Reviews Neurology, 2021 - nature.com
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight

JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Regional Aβ-tau interactions promote onset and acceleration of Alzheimer's disease tau spreading

WJ Lee, JA Brown, HR Kim, R La Joie, H Cho, CH Lyoo… - Neuron, 2022 - cell.com
Amyloid-beta and tau are key molecules in the pathogenesis of Alzheimer's disease, but it
remains unclear how these proteins interact to promote disease. Here, by combining cross …

Network neuroscience

DS Bassett, O Sporns - Nature neuroscience, 2017 - nature.com
Despite substantial recent progress, our understanding of the principles and mechanisms
underlying complex brain function and cognition remains incomplete. Network neuroscience …

Imaging the evolution and pathophysiology of Alzheimer disease

W Jagust - Nature Reviews Neuroscience, 2018 - nature.com
Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …

Communication dynamics in complex brain networks

A Avena-Koenigsberger, B Misic… - Nature reviews …, 2018 - nature.com
Neuronal signalling and communication underpin virtually all aspects of brain activity and
function. Network science approaches to modelling and analysing the dynamics of …

Local molecular and global connectomic contributions to cross-disorder cortical abnormalities

JY Hansen, G Shafiei, JW Vogel, K Smart… - Nature …, 2022 - nature.com
Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …