Inhibitory activities of indolizine derivatives: a patent review

KM Dawood, AA Abbas - Expert Opinion on Therapeutic Patents, 2020 - Taylor & Francis
Introduction Indolizines are structural isomers with indoles. Although several indole-based
commercial drugs are available in the market, none of the indolizine-based drugs are …

Tuberculosis: an update on pathophysiology, molecular mechanisms of drug resistance, newer anti-TB drugs, treatment regimens and host-directed therapies

P Borah, PK Deb, KN Venugopala… - Current Topics in …, 2021 - ingentaconnect.com
Human tuberculosis (TB) is primarily caused by Mycobacterium tuberculosis (Mtb) that
inhabits inside and amidst immune cells of the host with adapted physiology to regulate …

Design, synthesis, characterization, and anti-tubercular activity of novel ethyl-3-benzoyl-6, 8-difluoroindolizine-1-carboxylate analogues: Molecular target identification …

P Mundhe, S Kidwai, SM Saini, HR Singh… - Journal of Molecular …, 2023 - Elsevier
A series of novel Ethyl-3-benzoyl-6, 8-difluoroindolizine-1-carboxylate analogues (4a-r)
were synthesized by reacting 3, 5-difluoropyridine, with phenacyl bromide to get quaternary …

Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme

KN Venugopala, S Chandrashekharappa… - Journal of Enzyme …, 2021 - Taylor & Francis
Abstract A series of 1, 2, 3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were
screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and …

Investigation of antifungal properties of synthetic dimethyl-4-bromo-1-(substituted benzoyl) pyrrolo [1, 2-a] quinoline-2, 3-dicarboxylates analogues: Molecular docking …

V Uppar, S Chandrashekharappa, C Shivamallu, SP… - Molecules, 2021 - mdpi.com
Candida albicans, an opportunistic fungal pathogen, frequently colonizes immune-
compromised patients and causes mild to severe systemic reactions. Only few antifungal …

Synergy of clavine alkaloid 'chanoclavine' with tetracycline against multi-drug-resistant E. coli

GR Dwivedi, A Maurya, DK Yadav, V Singh… - Journal of …, 2019 - Taylor & Francis
The emergence of multi drug resistance (MDR) in Gram-negative bacteria (GNB) and lack of
novel classes of antibacterial agents have raised an immediate need to identify antibacterial …

Recent advances in the synthesis of new benzothiazole based anti-tubercular compounds

R Yadav, D Meena, K Singh, R Tyagi, Y Yadav… - RSC …, 2023 - pubs.rsc.org
This review highlights the recent synthetic developments of benzothiazole based anti-
tubercular compounds and their in vitro and in vivo activity. The inhibitory concentrations of …

Anti-Tubercular Properties of 4-Amino-5-(4-Fluoro-3- Phenoxyphenyl)-4H-1,2,4-Triazole-3-Thiol and Its Schiff Bases: Computational Input and Molecular Dynamics

KN Venugopala, M Kandeel, M Pillay, PK Deb… - Antibiotics, 2020 - mdpi.com
In the present investigation, the parent compound 4-amino-5-(4-fluoro-3-phenoxyphenyl)-4
H-1, 2, 4-triazole-3-thiol (1) and its Schiff bases 2, 3, and 4 were subjected to whole-cell anti …

Cytotoxicity and Antimycobacterial Properties of Pyrrolo[1,2-a]quinoline Derivatives: Molecular Target Identification and Molecular Docking Studies

KN Venugopala, V Uppar, S Chandrashekharappa… - Antibiotics, 2020 - mdpi.com
A series of ethyl 1-(substituted benzoyl)-5-methylpyrrolo [1, 2-a] quinoline-3-carboxylates 4a–
f and dimethyl 1-(substituted benzoyl)-5-methylpyrrolo [1, 2-a] quinoline-2, 3-dicarboxylates …

Synthesis and structural elucidation of novel benzothiazole derivatives as anti-tubercular agents: In-silico screening for possible target identification

KN Venugopala, S Chandrashekharappa… - Medicinal …, 2019 - ingentaconnect.com
Background: Benzothiazole derivatives are known for anti-TB properties. Based on the
known anti-TB benzothiazole pharmacophore, in the present study, we described the …