Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

Introduction Since the spread of chloroquine resistance in Plasmodium falciparum in the
1960s, recommendations have been made on how to respond to antimalarial resistance …

Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the
artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum …

Background. Deployment of mefloquine–artesunate (MAS3) on the Thailand–Myanmar
border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy …

We have analyzed the in vitro chemosensitivity profiles of 115 Kenyan isolates for
chloroquine (CQ), piperaquine, lumefantrine (LM), and dihydroartemisinin in association …

As drug-resistant falciparum malaria has continued to evolve and spread worldwide,
artemisinin-based combination therapies (ACT) have become the centerpiece of global …

Expanding drug resistance could become a major problem in malaria treatment, as only a
limited number of effective antimalarials are available. Drug resistance has been associated …

The recent reports of artemisinin (ART) resistance in the Thai–Cambodian border area raise
a serious concern on the long‐term efficacy of ARTs. To elucidate the resistance …

This systematic review elaborates the concepts and impacts of border malaria, particularly
on the emergence and spread of Plasmodium falciparum and Plasmodium vivax multidrug …

Single oral doses of artesunate, dihydroartemisinin, arteether and artemether administered
to rats during a sensitive period of organogenesis caused embryo deaths and malformations …