Chemical ecology of antibiotic production by actinomycetes

A Van der Meij, SF Worsley… - FEMS microbiology …, 2017 - academic.oup.com
Actinomycetes are a diverse family of filamentous bacteria that produce a plethora of natural
products relevant for agriculture, biotechnology and medicine, including the majority of the …

Marine actinomycetes, new sources of biotechnological products

SV Jagannathan, EM Manemann, SE Rowe… - Marine Drugs, 2021 - mdpi.com
The Actinomycetales order is one of great genetic and functional diversity, including diversity
in the production of secondary metabolites which have uses in medical, environmental …

Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

LK Caesar, R Montaser, NP Keller… - Natural product reports, 2021 - pubs.rsc.org
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …

Actinomycetes enrich soil rhizosphere and improve seed quality as well as productivity of legumes by boosting nitrogen availability and metabolism

H AbdElgawad, W Abuelsoud, MMY Madany, S Selim… - Biomolecules, 2020 - mdpi.com
The use of actinomycetes for improving soil fertility and plant production is an attractive
strategy for developing sustainable agricultural systems due to their effectiveness, eco …

Glycosyltransferases: mechanisms and applications in natural product development

DM Liang, JH Liu, H Wu, BB Wang, HJ Zhu… - Chemical Society …, 2015 - pubs.rsc.org
Glycosylation reactions mainly catalyzed by glycosyltransferases (Gts) occur almost
everywhere in the biosphere, and always play crucial roles in vital processes. In order to …

Antibiotic drug discovery

W Wohlleben, Y Mast, E Stegmann… - Microbial …, 2016 - Wiley Online Library
Due to the threat posed by the increase of highly resistant pathogenic bacteria, there is an
urgent need for new antibiotics; all the more so since in the last 20 years, the approval for …

The essentials of marine biotechnology

A Rotter, M Barbier, F Bertoni, AM Bones… - Frontiers In marine …, 2021 - frontiersin.org
Coastal countries have traditionally relied on the existing marine resources (eg, fishing,
food, transport, recreation, and tourism) as well as tried to support new economic endeavors …

YcaO-dependent posttranslational amide activation: biosynthesis, structure, and function

BJ Burkhart, CJ Schwalen, G Mann, JH Naismith… - Chemical …, 2017 - ACS Publications
With advances in sequencing technology, uncharacterized proteins and domains of
unknown function (DUFs) are rapidly accumulating in sequence databases and offer an …

Microbe-driven chemical ecology: past, present and future

R Schmidt, D Ulanova, LY Wick, HB Bode… - The ISME …, 2019 - academic.oup.com
In recent years, research in the field of Microbial Ecology has revealed the tremendous
diversity and complexity of microbial communities across different ecosystems. Microbes …

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

KS Ju, J Gao, JR Doroghazi… - Proceedings of the …, 2015 - National Acad Sciences
Although natural products have been a particularly rich source of human medicines, activity-
based screening results in a very high rate of rediscovery of known molecules. Based on the …