Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a
critical role in cancer. Although research often concentrates on the tumor's cellular aspect …

Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression.
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

The role of tumor microenvironment in cancer progression is gaining significant attention. It
is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells …

Besides molecular and phenotypic variations observed in cancer cells, intratumoral
heterogeneity also occurs in the tumor microenvironment. Correlative stiffness maps of …

Fibroblasts have exceptional phenotypic plasticity and capability to secrete vast amount of
soluble factors, extracellular matrix components and extracellular vesicles. While in …