Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity
H Cao, L Duan, Y Zhang, J Cao, K Zhang - Signal transduction and …, 2021 - nature.com
Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …
structure and functional design that leverages on material engineering to modulate its …
Targeting the tumor stroma for cancer therapy
M Xu, T Zhang, R Xia, Y Wei, X Wei - Molecular Cancer, 2022 - Springer
Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …
The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets
JJF Sleeboom, GS van Tienderen… - Science translational …, 2024 - science.org
The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a
critical role in cancer. Although research often concentrates on the tumor's cellular aspect …
critical role in cancer. Although research often concentrates on the tumor's cellular aspect …
Cellular mechanotransduction: from tension to function
F Martino, AR Perestrelo, V Vinarský, S Pagliari… - Frontiers in …, 2018 - frontiersin.org
Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …
The extracellular matrix in tumor progression and metastasis
JA Eble, S Niland - Clinical & experimental metastasis, 2019 - Springer
The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …
network of extracellular proteins, proteoglycans and glycoproteins, which form …
Matrix stiffness contributes to cancer progression by regulating transcription factors
S Ishihara, H Haga - Cancers, 2022 - mdpi.com
Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression.
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …
Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine
Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …
between the biophysical tumor microenvironment and genetic regulation has significant …
[HTML][HTML] Biophysics of tumor microenvironment and cancer metastasis-a mini review
The role of tumor microenvironment in cancer progression is gaining significant attention. It
is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells …
is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells …
Heterogeneous microenvironmental stiffness regulates pro-metastatic functions of breast cancer cells
Besides molecular and phenotypic variations observed in cancer cells, intratumoral
heterogeneity also occurs in the tumor microenvironment. Correlative stiffness maps of …
heterogeneity also occurs in the tumor microenvironment. Correlative stiffness maps of …
Cancer associated fibroblasts: the architects of stroma remodeling
A Santi, FG Kugeratski, S Zanivan - Proteomics, 2018 - Wiley Online Library
Fibroblasts have exceptional phenotypic plasticity and capability to secrete vast amount of
soluble factors, extracellular matrix components and extracellular vesicles. While in …
soluble factors, extracellular matrix components and extracellular vesicles. While in …