Neuroprotective effects of exercise on the aging human neuromuscular system

MD Allen, BH Dalton, KJ Gilmore, CJ McNeil… - Experimental …, 2021 - Elsevier
Human biological aging from maturity to senescence is associated with a gradual loss of
muscle mass and neuromuscular function. It is not until very old age (> 80 years) however …

Sarcopenia measurement in research and clinical practice

E Dent, J Woo, D Scott, EO Hoogendijk - European Journal of Internal …, 2021 - Elsevier
Sarcopenia is a disease related to accelerated loss of skeletal muscle and subsequent
decline in functional capacity. It affects approximately 13% of the world's population aged …

Association of low muscle mass with cognitive function during a 3-year follow-up among adults aged 65 to 86 years in the Canadian longitudinal study on aging

AJ Tessier, SS Wing, E Rahme, JA Morais… - JAMA network …, 2022 - jamanetwork.com
Importance Cross-sectional studies have shown that combined low muscle mass and
strength are associated with cognitive impairment. Whether low muscle mass, reflective of …

[HTML][HTML] Impact of using the updated EWGSOP2 definition in diagnosing sarcopenia: A clinical perspective

JM Van Ancum, J Alcazar, CGM Meskers… - Archives of gerontology …, 2020 - Elsevier
Abstract Background and Purpose The revised European Working Group on Sarcopenia in
Older People (EWGSOP2, version 2019) definition of sarcopenia differs with respect to the …

Toward the recognition and management of sarcopenia in routine clinical care

E Dent, J Woo, D Scott, EO Hoogendijk - Nature Aging, 2021 - nature.com
Sarcopenia, the age-associated decline in skeletal muscle mass and function, is a major
cause of functional decline and mortality in older adults. Despite its importance, sarcopenia …

Advances in exercise to alleviate sarcopenia in older adults by improving mitochondrial dysfunction

Y Zhu, X Zhou, A Zhu, S Xiong, J Xie, Z Bai - Frontiers in Physiology, 2023 - frontiersin.org
Sarcopenia is a chronic degenerative disease affecting primarily older adults. A growing
aging population is gradually increasing the number of patients suffering from sarcopenia …

Physical function‐derived cut‐points for the diagnosis of sarcopenia and dynapenia from the Canadian longitudinal study on aging

AJ Tessier, SS Wing, E Rahme… - Journal of Cachexia …, 2019 - Wiley Online Library
Background Aging is associated with sarcopenia (low muscle mass) and dynapenia (low
muscle strength) leading to disability and mortality. Widely used previous cut‐points for …

Exercise-induced mitohormesis for the maintenance of skeletal muscle and healthspan extension

RV Musci, KL Hamilton, MA Linden - Sports, 2019 - mdpi.com
Oxidative damage is one mechanism linking aging with chronic diseases including the
progressive loss of skeletal muscle mass and function called sarcopenia. Thus, mitigating …

Muscle Steatosis and Fibrosis in Older Adults, From the AJR Special Series on Imaging of Fibrosis

L Lenchik, V Mazzoli, PM Cawthon… - American Journal of …, 2024 - ajronline.org
The purpose of this article is to review steatosis and fibrosis of skeletal muscle, focusing on
older adults. Although CT, MRI, and ultrasound are commonly used to image skeletal …

The Dunkin Hartley Guinea pig is a model of primary osteoarthritis that also exhibits early onset myofiber remodeling that resembles human musculoskeletal aging

RV Musci, MA Walsh, AR Konopka, CA Wolff… - Frontiers in …, 2020 - frontiersin.org
Skeletal muscle dysfunction, articular cartilage degeneration, and bone loss occur
essentially in parallel during aging. Mechanisms contributing to this systemic …