Liquid–liquid phase separation in crowded environments
Biomolecular condensates play a key role in organizing cellular fluids such as the cytoplasm
and nucleoplasm. Most of these non-membranous organelles show liquid-like properties …
and nucleoplasm. Most of these non-membranous organelles show liquid-like properties …
RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation
JC Rengifo-Gonzalez, K El Hage, MJ Clément… - Elife, 2021 - elifesciences.org
TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two
major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its …
major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its …
[HTML][HTML] Valency and binding affinity variations can regulate the multilayered organization of protein condensates with many components
Biomolecular condensates, which assemble via the process of liquid–liquid phase
separation (LLPS), are multicomponent compartments found ubiquitously inside cells …
separation (LLPS), are multicomponent compartments found ubiquitously inside cells …
Molecular mechanisms behind mRNA localization in axons
B Turner-Bridger, C Caterino, JM Cioni - Open biology, 2020 - royalsocietypublishing.org
Messenger RNA (mRNA) localization allows spatiotemporal regulation of the proteome at
the subcellular level. This is observed in the axons of neurons, where mRNA localization is …
the subcellular level. This is observed in the axons of neurons, where mRNA localization is …
OsGRP3 Enhances Drought Resistance by Altering Phenylpropanoid Biosynthesis Pathway in Rice (Oryza sativa L.)
W Xu, Y Dou, H Geng, J Fu, Z Dan, T Liang… - International Journal of …, 2022 - mdpi.com
As a sessile organism, rice often faces various kinds of abiotic stresses, such as drought
stress. Drought stress seriously harms plant growth and damages crop yield every year …
stress. Drought stress seriously harms plant growth and damages crop yield every year …
The role of ubiquitin in regulating stress granule dynamics
LJ Krause, MG Herrera, KF Winklhofer - Frontiers in Physiology, 2022 - frontiersin.org
Stress granules (SGs) are dynamic, reversible biomolecular condensates, which assemble
in the cytoplasm of eukaryotic cells under various stress conditions. Formation of SGs …
in the cytoplasm of eukaryotic cells under various stress conditions. Formation of SGs …
RNA as the stone guest of protein aggregation
The study of prions as infectious aggregates dates several decades. From its original
formulation, the definition of a prion has progressively changed to the point that many …
formulation, the definition of a prion has progressively changed to the point that many …
Long non-coding RNA-ribonucleoprotein networks in the post-transcriptional control of gene expression
P Briata, R Gherzi - Non-coding RNA, 2020 - mdpi.com
Although mammals possess roughly the same number of protein-coding genes as worms, it
is evident that the non-coding transcriptome content has become far broader and more …
is evident that the non-coding transcriptome content has become far broader and more …
A novel intronic circular RNA circFGFR1int2 up-regulates FGFR1 by recruiting transcriptional activators P65/FUS and suppressing miR-4687-5p to promote prostate …
R Wang, J Zhong, X Pan, Z Su, Y Xu, M Zhang… - Journal of Translational …, 2023 - Springer
Fibroblast growth factor receptor 1 (FGFR1) is a core component of the FGFs/FGFR pathway
that activates multiple signalling pathways, including ERK1/2, PI3K/AKT, PLCγ, and NF-κB …
that activates multiple signalling pathways, including ERK1/2, PI3K/AKT, PLCγ, and NF-κB …