Alzheimer's disease (AD) is a deadly brain degenerative disorder that leads to brain
shrinkage and dementia. AD is manifested with hyperphosphorylated tau protein levels and …

A key challenge for domesticating alternative cultivable microorganisms with
biotechnological potential lies in the development of innovative technologies. Within this …

Emerging demands for handling minute liquid samples and reagents have been constantly
growing in a wide variety of medical and biological areas. This calls for low-volume and high …

Mini-bioreactor systems enabling automatized operation of numerous parallel cultivations
are a promising alternative to accelerate and optimize bioprocess development allowing for …

Modular type I polyketide synthases (PKSs) are multifunctional proteins that are comprised
of individual domains organized into modules. These modules act together to assemble …

Saccharomyces cerevisiae continues to serve as a powerful model system for both basic
biological research and industrial application. The development of genome-wide collections …

The drug discovery process in the biopharmaceutical industry usually starts with the
generation of plasmids coding for certain proteins. Due to advances in cloning techniques …

Agrobacterium-mediated transformation (AMT) potentially has great advantages over other
DNA introduction methods: eg, long DNA and numerous recipient strains can be dealt with …

Background The creation of arrays of yeast strains each encoding a different protein with
constant tags is a powerful method for understanding how genes and their proteins control …

Thèse présentée à la Faculté de médecine et des sciences de la santé en vue de l'obtention
du diplôme de philosophiae doctor (Ph. D.) en microbiologie, Faculté de médecine et des …