KRAS (kirsten rat sarcoma viral oncogene) is a member of the RAS family. KRAS mutations
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …

Signal transducer and activator of transcription 3 (STAT3) plays crucial roles in several
cellular processes such as cell proliferation and survival, and has been found to be …

Cancer is as unique as the person fighting it. With the exception of a few biomarker-driven
therapies, patients go through rounds of trial-and-error approaches to find the best …

Various human malignancies are characterized by excessive activation of the Janus family
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …

Data from many preclinical studies, including those using cellular models of colorectal,
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …

Targeting the KRAS pathway is a promising but challenging approach for colorectal cancer
therapy. Despite showing potent efficacy in BRAF-mutated melanoma, MEK inhibitors …

ABSTRACT ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor
prognosis in many malignancies, including in patients treated with PD-(L) 1 inhibitors. The …

The mitogen-activated protein kinases (MAPKs) mediate intracellular signals activated by a
wide variety of extracellular stimuli. The activation of the RAS-RAF-MEK-MAPK cascade …

Adenosine plays an important role in inflammation and tumor development, progression,
and responses to therapy. We show that an adenosine 2B receptor inhibitor (A2BRi) …

Since its discovery, ADAM17, also known as TNFα converting enzyme or TACE, is now
known to process over 80 different substrates. Many of these substrates are mediators of …