Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy

AG Singal, F Kanwal, JM Llovet - Nature reviews Clinical oncology, 2023 - nature.com
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …

AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma

AG Singal, JM Llovet, M Yarchoan, N Mehta… - Hepatology, 2023 - journals.lww.com
This guidance document provides an updated approach to the prevention, diagnosis, and
treatment of hepatocellular carcinoma (HCC). The prior American Association for the Study …

Financial burden of hepatocellular carcinoma screening in patients with cirrhosis

M Narasimman, R Hernaez, V Cerda, MJ Lee… - Clinical …, 2024 - Elsevier
Background The overall value of hepatocellular carcinoma screening is defined by the
balance of benefits and harms. Studies have only reported physical harms with none …

The Future Role of Abdominal US in Hepatocellular Carcinoma Surveillance

M Mendiratta-Lala, D Fetzer, A Kamaya, ND Parikh… - Radiology, 2024 - pubs.rsna.org
Abdominal US is currently the best-validated surveillance strategy for hepatocellular
carcinoma (HCC) in at-risk patients. It is the only modality shown to have completed all five …

Hepatocellular carcinoma surveillance patterns and outcomes in patients with cirrhosis

D Daher, KS El Dahan, A Cano, M Gonzales… - Clinical …, 2024 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) surveillance is associated with
improved early detection and reduced mortality, although practice patterns and effectiveness …

Screening for Hepatocellular Carcinoma and Survival in Patients With Cirrhosis After Hepatitis C Virus Cure

C Mezzacappa, NJ Kim, P Vutien, DE Kaplan… - JAMA Network …, 2024 - jamanetwork.com
Importance The risk of hepatocellular carcinoma (HCC) declines over time after hepatitis C
virus (HCV) cure by direct-acting antiviral (DAA) therapies. Liver society guidelines …

Hepatocellular Carcinoma Screening in a Contemporary Cohort of At-Risk Patients

D Daher, KS El Dahan, NE Rich, N Tayob… - JAMA Network …, 2024 - jamanetwork.com
Importance Cohort studies demonstrating an association of hepatocellular carcinoma (HCC)
screening with reduced mortality are prone to lead-time and length-time biases. Objective To …

Cost-Effectiveness of a Biomarker-Based Screening Strategy for Hepatocellular Carcinoma in Patients with Cirrhosis

AG Singal, J Chhatwal, N Parikh, E Tapper - Liver Cancer, 2024 - karger.com
Introduction: Given suboptimal performance of ultrasound-based surveillance for early
hepatocellular carcinoma (HCC) detection in patients with cirrhosis, there is interest in …

Benefits and Harms of Hepatocellular Carcinoma Screening Outreach in Patients with Cirrhosis: A Multi-Center Randomized Clinical Trial

AG Singal, D Daher, M Narasimman… - JNCI: Journal of the …, 2024 - academic.oup.com
Background The value of hepatocellular carcinoma (HCC) screening is defined by the
balance of benefits from early tumor detection vs harms due to false positive results. We …

[HTML][HTML] Role of Imaging in Screening for Hepatocellular Carcinoma

IA Kazi, V Jahagirdar, BW Kabir, AK Syed, AW Kabir… - Cancers, 2024 - mdpi.com
Simple Summary Liver cancer ranks as the sixth most common type of cancer and is the
third leading cause of cancer deaths. The most frequent type of liver cancer is hepatocellular …