Molecular biomarkers in cancer

VK Sarhadi, G Armengol - Biomolecules, 2022 - mdpi.com
Molecular cancer biomarkers are any measurable molecular indicator of risk of cancer,
occurrence of cancer, or patient outcome. They may include germline or somatic genetic …

RNAi-based therapeutics and tumor targeted delivery in cancer

G Kara, GA Calin, B Ozpolat - Advanced drug delivery reviews, 2022 - Elsevier
Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …

[HTML][HTML] Traditional Chinese medicine for precancerous lesions of gastric cancer: a review

W Xu, B Li, M Xu, T Yang, X Hao - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Gastric cancer (GC) is the fifth most common type of cancer and the third leading cause of
death due to cancer worldwide. The gastric mucosa often undergoes many years of …

MiRNAs and cancer: key link in diagnosis and therapy

Y Shi, Z Liu, Q Lin, Q Luo, Y Cen, J Li, X Fang, C Gong - Genes, 2021 - mdpi.com
Since the discovery of the first microRNA (miRNA), the exploration of miRNA biology has
come to a new era in recent decades. Monumental studies have proven that miRNAs can be …

Artificial intelligence, healthcare, clinical genomics, and pharmacogenomics approaches in precision medicine

H Abdelhalim, A Berber, M Lodi, R Jain, A Nair… - Frontiers in …, 2022 - frontiersin.org
Precision medicine has greatly aided in improving health outcomes using earlier diagnosis
and better prognosis for chronic diseases. It makes use of clinical data associated with the …

LncRNA XIST promotes pancreatic cancer proliferation through miR‐133a/EGFR

W Wei, Y Liu, Y Lu, B Yang… - Journal of cellular …, 2017 - Wiley Online Library
According to recent studies, long non‐coding RNA X‐inactive specific transcript (XIST) is
involved in the development and progression of many malignant tumors including …

Editorial focus: understanding off-target effects as the key to successful RNAi therapy

R Bartoszewski, AF Sikorski - Cellular & molecular biology letters, 2019 - Springer
With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we
witness the RNAi therapy field reaching a critical turning point, when further improvements in …

The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation

S Li, Y Huang, Y Huang, Y Fu, D Tang, R Kang… - Journal of experimental …, 2017 - Springer
Abstract Background P73 antisense RNA 1 T (non-protein coding), also known as TP73-
AS1, is a long non-coding RNA (lncRNA) which is involved in cell proliferation and the …

Update on uveal melanoma: Translational research from biology to clinical practice

MA Ortega, O Fraile-Martinez… - International …, 2020 - spandidos-publications.com
Uveal melanoma is the most common type of intraocular cancer with a low mean annual
incidence of 5-10 cases per million. Tumours are located in the choroid (90%), ciliary body …

[HTML][HTML] Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions

RKME Alsayed, KSAM Sheikhan, MA Alam… - Seminars in Cancer …, 2023 - Elsevier
Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cancer cells to
indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a …