[HTML][HTML] Mechanics in the nervous system: From development to disease
Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …
This review highlights the significance of mechanical forces in nervous system development …
Structural LTP: Signal transduction, actin cytoskeleton reorganization, and membrane remodeling of dendritic spines
Y Yang, JJ Liu - Current Opinion in Neurobiology, 2022 - Elsevier
Induction of long-term synaptic potentiation (LTP) in excitatory neurons triggers a transient
enlargement of dendritic spines followed by decay to sustained size expansion, a process …
enlargement of dendritic spines followed by decay to sustained size expansion, a process …
Multiscale mechanobiology in brain physiology and diseases
Increasing evidence suggests that mechanics play a critical role in regulating brain function
at different scales. Downstream integration of mechanical inputs into biochemical signals …
at different scales. Downstream integration of mechanical inputs into biochemical signals …
Mechanical regulation of synapse formation and plasticity
T Minegishi, RF Kastian, N Inagaki - Seminars in Cell & Developmental …, 2023 - Elsevier
Dendritic spines are small protrusions arising from dendrites and constitute the major
compartment of excitatory post-synapses. They change in number, shape, and size …
compartment of excitatory post-synapses. They change in number, shape, and size …
Actin cytoskeleton role in the maintenance of neuronal morphology and long-term memory
R Lamprecht - Cells, 2021 - mdpi.com
Evidence indicates that long-term memory formation creates long-lasting changes in
neuronal morphology within a specific neuronal network that forms the memory trace …
neuronal morphology within a specific neuronal network that forms the memory trace …
Adhesion-clutch between DCC and netrin-1 mediates netrin-1–induced axonal haptotaxis
Z Qiu, T Minegishi, D Aoki, K Abe, K Baba… - Frontiers in Molecular …, 2024 - frontiersin.org
The growth cone, a motile structure located at the tip of growing axons, senses extracellular
guidance cues and translates them into directional forces that drive axon outgrowth and …
guidance cues and translates them into directional forces that drive axon outgrowth and …
Biophysical modeling of actin-mediated structural plasticity reveals mechanical adaptation in dendritic spines
M Bonilla-Quintana, P Rangamani - Eneuro, 2024 - eneuro.org
Synaptic plasticity is important for learning and memory formation; it describes the
strengthening or weakening of connections between synapses. The postsynaptic part of …
strengthening or weakening of connections between synapses. The postsynaptic part of …
Analyses of actin dynamics, clutch coupling and traction force for growth cone advance
T Minegishi, R Fujikawa, RF Kastian… - JoVE (Journal of …, 2021 - jove.com
To establish functional networks, neurons must migrate to their appropriate destinations and
then extend axons toward their target cells. These processes depend on the advances of …
then extend axons toward their target cells. These processes depend on the advances of …
Shootin1 Regulates Retinal Ganglion Cell Neurite Development: Insights From an RGC Direct Somatic Cell Reprogramming Model
K Zhang, T Zhang, Q He, H Liang, J Guo… - … & Visual Science, 2024 - iovs.arvojournals.org
Purpose: Retinal ganglion cells (RGCs) connect the retina to the brain. Proper development
of the axons and dendrites of RGCs is the basis for these cells to function as projection …
of the axons and dendrites of RGCs is the basis for these cells to function as projection …
Altered amantadine effects after repetitive treatment for l-dopa-induced involuntary movements in a rat model of Parkinson's disease
Y Murakami, H Nishijima, T Nakamura, T Furukawa… - Neuroscience …, 2023 - Elsevier
Abstract Background l-3, 4-dihydroxyphenylalanine (l-dopa) is the most effective drug for
Parkinson's disease (PD); however, most PD patients develop motor fluctuations including …
Parkinson's disease (PD); however, most PD patients develop motor fluctuations including …