The vital roles of microtubule in mitosis and cell division make it an attractive target for
antitumor therapy. Colchicine binding site of tubulin is one of the most important pockets that …

The combretastatins are isolated from South African tree combretum caffrum kuntze. The
lead compound combretastatin A-4 has displayed remarkable cytotoxic effect in a wide …

The urea functionality is inherent to numerous bioactive compounds, including a variety of
clinically approved therapies. Urea containing compounds are increasingly used in …

Abstract The styryl (Ph‐CH= CH‐R) group is widely represented in medicinally important
compounds, including drugs, clinical candidates, and molecular probes as it positively …

Abstract Thirty-two novel 3-alkylsulfanyl-1, 2, 4-triazole derivatives, designed as cis-
restricted combretastatin A-4 analogues, were synthesized and evaluated for their …

Malignant melanoma (MM) is the most lethal skin cancer. Despite a 4% reduction in mortality
over the past few years, an increasing number of new diagnosed cases appear each year …

In order to design and synthesize a new class of heterocyclic analogues of natural
combretastatin A-4 and its synthetic derivative AVE8062, the benzoxazolone ring was …

We have synthesized a series of new β-lactam-azide derivatives as orally active anti-tumor
agents by targeting tubulin colchicine binding site and examined their structure activity …

A series of novel N-substituted 3-oxo-1, 2, 3, 4-tetrahydro-quinoxaline-6-carboxy-lic acid
derivatives were synthesized and evaluated for their biological activities. Among all …

Tubulin targeting agents have received considerable interest as a potential tumor-selective
vascular disrupting agents, which represent another avenue for cancer growing therapeutic …