Recent progress in the synthesis and chemistry of azetidinones

GS Singh - Tetrahedron, 2003 - Elsevier
Natural and synthetic azetidinone derivatives occupy a central place among medicinally
important compounds due to their diverse and interesting antibiotic activities. 1–9 Even …

The chemistry and biological potential of azetidin-2-ones

N Arya, AY Jagdale, TA Patil, SS Yeramwar… - European journal of …, 2014 - Elsevier
Abstract Azetidin-2-ones, commonly referred as β-lactams, represent a unique ring system,
with interesting chemistry and great biological potential. Besides its well known antibiotic …

Carbamoyl Radical‐Mediated Synthesis and Semipinacol Rearrangement of β‐Lactam Diols

M Betou, L Male, JW Steed… - Chemistry–A European …, 2014 - Wiley Online Library
In an approach to the biologically important 6‐azabicyclo [3.2. 1] octane ring system, the
scope of the tandem 4‐exo‐trig carbamoyl radical cyclization—dithiocarbamate group …

Synthesis and reactivity of spiro-fused β-lactams

GS Singh, M D'hooghe, N De Kimpe - Tetrahedron, 2011 - Elsevier
2-Azetidinones, commonly known as b-lactams, are the key structural motifs in the most
widely used class of antibiotics, ie, b-lactam antibiotics, such as penicillins, cephalosporins …

Palladium-catalyzed intramolecular selenocarbamoylation of alkynes with carbamoselenoates: formation of α-alkylidene-β-lactam framework

M Toyofuku, S Fujiwara, T Shin-ike… - Journal of the …, 2005 - ACS Publications
Palladium-Catalyzed Intramolecular Selenocarbamoylation of Alkynes with
Carbamoselenoates: Formation of α-Alkylidene-β-lactam Framework | Journal of the …

Synthesis of mono-, bis-spiro-and dispiro-β-lactams and evaluation of their antimalarial activities

A Jarrahpour, E Ebrahimi, E De Clercq, V Sinou… - Tetrahedron, 2011 - Elsevier
Some new mono-, bis-spiro-and dispiro-β-lactams have been synthesized from imines
derived from 9H-fluoren-9-one and a ketene derived from 9H-xanthene-9-carboxylic acid or …

Dioxirane epoxidation of alkenes

W Adam, CR Saha‐Möller, CG Zhao - Organic Reactions, 2004 - Wiley Online Library
An ideal oxidant should be highly reactive, selective, and environmentally benign. It should
transform a broad range of substrates with diverse functional groups, preferably under …

Synthesis of α-Methylene-β-Lactams via PPh3-Catalyzed Umpolung Cyclization of Propiolamides

L Zhu, Y Xiong, C Li - The Journal of Organic Chemistry, 2015 - ACS Publications
We report herein a facile synthesis of α-methylene-β-lactams. Thus, under the catalysis of
triphenylphosphine, a number of 2-propiolamidoacetates or α-propiolamido ketones in …

Spirocyclic β-lactams: synthesis and biological evaluation of novel heterocycles

SS Bari, A Bhalla - Heterocyclic Scaffolds I: ß-Lactams, 2010 - Springer
Abstract β-Lactam rings containing compounds are a group of antibiotics of unparalleled
importance in chemotherapy. Considerable effort has been reported in the development of …

Synthesis of β‐Amino Acid Derivatives via Enantioselective Lewis Base Catalyzed N‐Allylation of Halogenated Amides with Morita‐Baylis‐Hillman Carbonates

O Nosovska, P Liebing… - Chemistry–A European …, 2024 - Wiley Online Library
Trifluoro‐and trichloroacetamides serving as pronucleophiles undergo enantioselective
Lewis base catalyzed N‐allylation with Morita‐Baylis‐Hillman carbonates to produce …