Brain organoids, or cerebral organoids, have become widely used to study the human brain
in vitro. As pluripotent stem cell-derived structures capable of self-organization and …

A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of
toxicological hazard information for most compounds. Therefore, new approaches are being …

Objective: Because the d-2-hydroxyglutarate (D2HG) product of mutant isocitrate
dehydrogenase 1 (IDH1mut) is released by tumor cells into the microenvironment and is …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

In the body, nanoparticles can be systemically distributed and then may affect secondary
target organs, such as the central nervous system (CNS). Putative adverse effects on the …

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …

Microelectrode array (MEA) approaches have been proposed as a tool for detecting
functional changes in electrically excitable cells, including neurons, exposed to drugs …

Drug-induced seizure liabilities produce significant compound attrition during drug
discovery. Currently available in vitro cytotoxicity assays cannot predict all toxicity …

Evidence implicates environmental factors in the pathogenesis of Autism Spectrum
Disorders (ASD). However, the identity of specific environmental chemicals that influence …

In vivo developmental neurotoxicity (DNT) testing is resource intensive and lacks information
on cellular processes affected by chemicals. To address this, DNT new approach …