The transformation of normal cells to the cancerous stage involves multiple genetic changes
or mutations leading to hyperproliferation, resistance to apoptosis, and evasion of the host …

Hematologic malignancies (HMs) mainly include acute and chronic leukemia, lymphoma,
myeloma and other heterogeneous tumors that seriously threaten human life and health …

Interaction between stromal cells and acute myeloid leukemia (AML) cells in bone marrow
(BM) is known to contribute importantly to chemoresistance and disease recurrence …

Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis. Here,
we studied the effects of phenformin, a mitochondrial complex I inhibitor and more potent …

This retrospective cohort study investigated whether metformin may reduce gastric cancer
risk by using the reimbursement databases of the Taiwan's National Health Insurance …

In the last decade, immune therapies against human cancers have emerged as a very
effective therapeutic strategy in the treatment of various cancers, some of which are resistant …

Multiple drug resistant (MDR) malignancy remains a predictable and often terminal event in
cancer therapy, and affects individuals with many cancer types, regardless of the stage at …

Mitochondria are energy-generated organelles and take an important part in biological
metabolism. Mitochondria could be transferred between cells, which serves as a new …

Mitochondria have long been controversial organelles in cancer. Early discoveries in cancer
metabolism placed much emphasis on cytosolic contributions. Initial debate focused on if …

Metformin, a widely used anti-diabetic molecule, has attracted a strong interest in the last 10
years as a possible new anti-cancer molecule. Metformin acts by interfering with …